vii

DAFTAR ISI

HALAMAN JUDUL........................................................................................ i

HALAMAN PENGESAHAN.......................................................................... ii

SURAT PERNYATAAN PLAGIARISME .................................................... iii

PRAKATA....................................................................................................... iv

DAFTAR ISI.................................................................................................... vii

DAFTAR TABEL............................................................................................ ix

INTISARI......................................................................................................... xiv

BAB I PENDAHULUAN........................................................................... 1

1.1. Latar Belakang ....................................................................... 1

1.2. Rumusan Masalah .................................................................. 3

1.3. Tujuan Penelitian .................................................................. 3

1.4. Manfaat Penelitian ................................................................ 4

BAB II TINJAUAN PUSTAKA.................................................................. 5

2.1. Derajat Demam Berdarah Dengue ........................................ 5

2.2. Demam Berdarah Dengue ..................................................... 5

2.2.1. Definisi ....................................................................... 5

2.2.2. Epidemiologi .............................................................. 6

2.2.3. Etiologi ...................................................................... 6

2.2.4. Manifestasi Klinis ..................................................... 7

2.2.5. Patogenesis ................................................................ 8

2.2.6. Patofisiologi ............................................................... 9

2.2.7. Penegakan Diagnosis.................................................. 12

viii

2.2.7.1. Anamnesis .................................................... 12

2.2.7.2. Pemeriksaan Fisik ........................................ 13

2.2.7.3. Pemeriksaan Penunjang ............................... 13

2.3. Hubungan kadar Hematokrit dengan Derajat penyakit Demam

Berdarah Dengue ................................................................... 15

2.4. Hubungan kadar Trombosit dengan Derajat penyakit Demam

Berdarah Dengue ................................................................... 16

2.5. Kerangka Teori ...................................................................... 18

2.6. Kerangka Konsep .................................................................. 19

2.7. Hipotesis................................................................................. 19

BAB III METODE PENELITIAN ................................................................ 20

3.1. Jenis Penelitian dan Rancangan Penelitian ............................ 20

3.2. Variabel dan Definisi Operasional ......................................... 20

3.2.1. Variabel Penelitian ..................................................... 20

3.2.2. Definisi Operasional................................................... 20

3.3. Populasi dan Sampel .............................................................. 21

3.3.1. Populasi Penelitian ..................................................... 21

3.3.2. Metode Pengambilan Sampel..................................... 22

3.3.2.1. Kriteria Inklusi ............................................. 22

3.3.2.2. Kriteria Eksklusi........................................... 22

3.3.2.3. Besar Sampel ............................................... 22

3.4. Instrumen dan Bahan Penelitian............................................. 23

3.5. Cara Penelitian ....................................................................... 23

3.6. Tempat dan Waktu ................................................................. 24

3.7. Analisa Hasil .......................................................................... 24

ix

BAB IV HASIL PENELITIAN DAN PEMBAHASAN............................... 26

4.1. Hasil Penelitian ...................................................................... 26

4.1.1 Hasil Sampel Penelitian ............................................ 26

4.1.2 Hasil Data Penelitian .................................................. 27

4.1.3 Hubungan kadar Hematokrit dengan derajat penyakit

DBD ........................................................................... 29

4.1.4 Hubungan kadar trombosit dengan derajat penyakit

DBD ........................................................................... 30

4.2 Pembahasan............................................................................ 32

BAB V KESIMPULAN DAN SARAN ....................................................... 37

5.1. Kesimpulan ............................................................................ 37

5.2. Saran....................................................................................... 38

DAFTAR PUSTAKA ...................................................................................... 39