iii

ABSTRAK

Pengujian ekstrak etanol daun ubi jalar (Ipomoea batatas (L.) Poir.) dan herba

pegagan (Centella asiatica (L.) Urb.) terhadap jumlah trombosit, eritrosit, dan

kadar hematokrit telah diteliti pada tikus putih jantan galur wistar (Rattus

novergicus) dengan metode induksi heparin. Ekstrak diberikan secara oral selama

7 hari berturut-turut, dosis ekstrak etanol daun ubi jalar dan ekstrak etanol herba

pegagan yang diberikan yaitu masing-masing 250 mg/kgBB dan 500 mg/kgBB.

Pengamatan terhadap parameter-parameter tersebut dilakukan pada hari ketujuh

dengan menggunakan alat Hematology analyzer sysmex XE-5000. Hasil penelitian

terhadap jumlah trombosit menunjukkan bahwa ekstrak etanol herba pegagan

pada dosis 500 mg/kgBB memiliki perbedaan nyata terhadap kontrol negatif pada

taraf nyata α=0,05 dengan persentase peningkatan jumlah trombosit sebesar

36,02% terhadap kontrol negatif. Hasil penelitian terhadap jumlah eritrosit dan

kadar hematokrit menunjukkan bahwa ekstrak etanol daun ubi jalar dosis 500

mg/kgBB dan ekstrak etanol herba pegagan dosis 500 mg/kgBB memiliki

perbedaan nyata terhadap kontrol negatif pada taraf nyata α=0,05 dimana

peningkatan jumlah eritrosit yang paling besar yaitu ekstrak etanol daun ubi jalar

dosis 500 mg/kgBB dengan persentase peningkatan jumlah eritrosit sebesar

10,95% terhadap kontrol negatif, dan peningkatan kadar hematokrit yang paling

besar yaitu ekstrak etanol daun ubi jalar dosis 500 mg/kgBB dengan persentase

peningkatan kadar hematokrit sebesar 9,08% terhadap kontrol negatif.

Kata kunci: Trombosit, Eritrosit, Hematokrit, Daun ubi jalar (Ipomoea batatas

(L.) Poir.), Herba pegagan (Centella asiatica (L.) Urb.)

FAKULT

AS FARM

ASI

UNIVERSIT

AS PADJA

DJARAN

iv

ABSTRACT

The aim of this research was to determine the effects of ethanol extracts of sweet

potato leaves (Ipomoea batatas (L.) Poir.) and pegagan herb (Centella asiatica

(L.) Urb.) against the number of thrombocytes, erythrocytes, and hematocrit

levels on male white rats (Rattus novergicus ) by using Heparin Induction

Method. Extracts was given orally for 7 continous days, the sweet potato leaves

ethanol extract and the pegagan herb ethanol extract dosages used are 250

mg/kgBW and 500 mg/kgBW. Observation of the parameters was tested on the

seventh day with using Hematology analyzer sysmex XE-5000. The results showed

that the rats group which are given ethanol extract of pegagan herb 500

mg/kgBW dosage gave a significant differences in numbers of thrombocytes

against negative control group (α=0.05) with a percentage value 36.02%. The

rats group which are given ethanol extract of sweet potato leaves 500 mg/kgBW

dosage and ethanol extract of pegagan herb 500 mg/kgBW dosage gave a

significant differences in numbers of erythrocytes and hematocrit levels against

negative control group (α=0.05). Sweet potato leaves extract at dosage 500

mg/kgBW gave the highest effect in increasing rats eyithrocytes number against

negative control with a percentage value 10.95%. Sweet potato leaves extract at

dosage 500 mg/kgBW gave the highest effect in increasing rats hematocrit levels

against negative control with a percentage value 9,08%.

Keyword : Thrombocyte, Erythrocyte, Hematocrit, Sweet potato leaves (Ipomoea

batatas (L.) Poir.), Pegagan herb (Centella asiatica (L.) Urb.)

FAKULT

AS FARM

ASI

UNIVERSIT

AS PADJA

DJARAN