Argipressin
1
Reactions 607 - 29 Jun 1996 S Argipressin Skin disorders: case report A 53-year-old man developed a purpuric and necrotic skin reaction after his oesophageal varices were treated with IV argipressin [Pitressin ® ; 8-arginine vasopressin]. The patient received IV argipressin 0.1 U/min increasing to 0.3 U/min for 24 hours. The dose was decreased to 0.2 U/min the following day as active oesophageal bleeding had stopped. Two days later, purpuric plaques with surrounding erythema were seen on his left flank and similar lesions with tense bullae were found on his right flank. His scrotum appeared necrotic with violaceous plaques. Argipressin was discontinued and a punch biopsy specimen showed that keratinocytes within the lower portion of his epidermis were extensively necrotic. His skin lesions were treated topically with bacitracin and healed over the next 17 days. Author comment: ‘Physicians should be aware of this rare but important complication of a method commonly used to treat bleeding esophageal varices.’ Lemlich G, et al. Cutaneous reaction to vasopressin. Cutis 57: 330-332, May 1996 - USA 800448684 1 Reactions 29 Jun 1996 No. 607 0114-9954/10/0607-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Argipressin
Reactions 607 - 29 Jun 1996
SArgipressin
Skin disorders: case reportA 53-year-old man developed a purpuric and necrotic skin
reaction after his oesophageal varices were treated with IVargipressin [Pitressin®; 8-arginine vasopressin].
The patient received IV argipressin 0.1 U/min increasing to0.3 U/min for 24 hours. The dose was decreased to 0.2 U/minthe following day as active oesophageal bleeding had stopped.Two days later, purpuric plaques with surrounding erythemawere seen on his left flank and similar lesions with tense bullaewere found on his right flank. His scrotum appeared necroticwith violaceous plaques.
Argipressin was discontinued and a punch biopsy specimenshowed that keratinocytes within the lower portion of hisepidermis were extensively necrotic. His skin lesions weretreated topically with bacitracin and healed over the next 17days.
Author comment: ‘Physicians should be aware of this rarebut important complication of a method commonly used totreat bleeding esophageal varices.’Lemlich G, et al. Cutaneous reaction to vasopressin. Cutis 57: 330-332, May 1996- USA 800448684
1
Reactions 29 Jun 1996 No. 6070114-9954/10/0607-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
