First name: Syed Nasir Abbas Last name: Bukhari Date of birth: 3rd of September 1986 Permanent Address: 8401, West Dempster St. Apt. K-2, Niles, 6014, IL, USA Present Address: Faculty of pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300,Kuala Lumpur, Malaysia Tel: 0060-1123695295 E-mail: snabphd@yahoo.com; snab@ukm.edu.my

2014 (August) – to date: Senior Lecturer (Medicinal Chemistry), Faculty of pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300,Kuala Lumpur, Malaysia.

2013 (July)/ (August) 2014: Postdoctoral Researcher, Drug and Herbal Research Center, Faculty of pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300,Kuala Lumpur, Malaysia.

2009 (December) / (May) 2013: PhD Thesis « Synthesis and biological evaluation of curcumin analogues and chalcone derivatives », realized at the Synthesis and Natural products Laboratory, UKM, Kuala Lumpur, Malaysia.

2009 (December) / (December) 2012: Post Graduate Research Assistant/Lab Demonstrator, Synthesis Lab, Faculty of pharmacy, University Kebangsaan Malaysia.

2009 (May) / (December) 2009: Postgraduate Researcher, faculty of pharmacy, University of Sargodha, Sargodha.

2004 (May) / (August) 2004: Handling and training of analytical instruments Hi-Tech Lab, Faculty of Pharmacy, University of Sargodha.

2007 (August) / (September) 2008: Clinical pharmacy house job as part of PharmD curriculum in DHQ teaching hospital Sargodha.

2009 /2013: PhD (December 22nd, 2009–May 22nd, 2013) Pharmacy (Medicinal chemistry), University Kebangsaan Malaysia, Kuala Lumpur Malaysia.

2003 /2009: PharmD (Doctor of Pharmacy), University of Sargodha, Sargodha. 2003 /2005: BSc (Bachelor of Science), University of Sargodha, Sargodha.

Synthesis of Novel bioactive compounds, Polymers, Biomaterials, Click chemistry, Drug delivery, Bioassay, Molecular Modelling, Biological evaluation of Natural products, Drug Discovery, Cell Biology, Immunology, Anticancer Drug Resistance, Anti-tubercular Agents, Ant-inflammatory and Immunomodulatory agents.

Biological: Development and/or realization of pharmacological tests on activities of players of immune system. Synthesis: Synthesis of novel compounds by various synthetic methods. Teaching and supervision: Regularly conducted practical for undergraduate students and have supervised the

undergraduate research projects of 8 final year students. Have lead several seminars for undergraduates in the faculty of pharmacy.

Linguistic: English (read, spoken, written); Urdu (read, spoken, written); Punjabi (mother tongue). Computing: Office, scientific software (SciFinder, ChemDraw).

Synthesis of various compounds including: Curcumin analogues, Chalcones, Pyrazolines, Isoxazoles derivatives Evaluation of newly synthesized compounds for: Anti Tubercular activity, Immunomodulatory effects including

monitoring of PMN Chemotaxis, Phagocytosis, Intracellular and Extracellular Reactive Oxygen Species production.

PROFESSIONAL EXPERIENCE PROFESSIONAL EXPERIENCEPROFESSIONAL

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EDUCATION PROFESSIONAL EXPERIENCEPROFESSIONAL

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COMPETENCES (others then Pharmacist) PROFESSIONAL EXPERIENCEPROFESSIONAL

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PhD RESEARCH WORK

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RESEARCH INTERESTS

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Prof. Dr. Scott G Franzblau

Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Illinois, USA

Prof. Dr. David R. Schubert

Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, CA, USA

Prof. Dr. Sylte, Ingebrigt

Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, University of

Tromsø, Tromsø, Norway

Prof. Dr. Hai-Liang Zhu

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China

Prof. Dr. Viresh H Shah

Department of Chemistry, Saurashtra University, Rajkot - 360 005, Gujarat, India

Prof. Dr. Hua-Li Qin

Department of Pharmaceutical Engineering, School of Chemical Engineering, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, P.R. China

Dr. Vijay H. Masand

Department of Chemistry, Vidya Bharati Mahavidyalaya, Amravati, Maharashtra 444 602, India

Prof. Dr. Oya Unsal Tan

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Turkey

Prof. Dr. Giuseppe Bifulco

Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084 Fisciano (SA), Italy

Award of “Excellent student for the Doctor of Philosophy Programme” Academic Session 2012-2013, Faculty of Pharmacy, UKM, Malaysia

University Research Scholarship award "Zamalah Universiti Kebangsaan Malaysia; Zamalah Universiti Penyelidikan. (2010-2012)

Award of "Partial Support for PhD Studies Abroad" Scholarship by Higher Education Commision (HEC) Pakistan.(2011-2012)

Best Student award for year 2004, PharmD session 2003-2008 Pride of performance award for PharmD session 2003-2008

7th Indochina Conference on Pharmaceutical Sciences Dec 14th-16th Bangkok Thailand (Poster presentation) Asian Federation for Pharmaceutical Science Conference Dec 9th-12th 2011 Kuala Lumpur, Malaysia. 1st International Postgraduate Conference on Pharmaceutical Sciences (iPoPS) 28th – 30th June 2012,

Selangor, Malaysia.

Syed Nasir Abbas Bukhari*, Xin Zhang, Ibrahim Jantan, Hai-Liang Zhu, Muhammad Wahab Amjad and Vijay H. Masand. Synthesis, Molecular Modeling and Biological Evaluation of Novel 1, 3-Diphenyl-2-propen-1-one Based Pyrazolines as Anti-inflammatory Agents. Chemical Biology & Drug Design. Accepted (In-press). DOI: 10.1111/cbdd.12457.

Kamal Rullah, Mohd Fadhlizil Fasihi Mohd Aluwi, Bohari M Yamin, Mohd Syukri Baharuddin, Nor Hadiani Ismail, Hilwan Yuda Teruna, Syed Nasir Abbas Bukhari, Ibrahim Jantan, Juriyati Jalil, Khairana Husain, Lam Kok Wai. Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor. Journal of Molecular Structure. Volume 1081, 5 February 2015, Pages 51–61.

Mohamed Ali Seyed, Ibrahim Jantan, and Syed Nasir Abbas Bukhari, “Emerging Anticancer Potentials of Goniothalamin and Its Molecular Mechanisms,” BioMed Research International, vol. 2014, Article ID 536508, 10 pages, 2014. doi:10.1155/2014/536508.

Ibrahim Jantan, Syed Nasir Abbas Bukhari*, Olayiwola A. Adekoya, Ingebrigt Sylte. Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines. Drug Design, Development and Theray.2014:8 1405–1418.

COLLABORATIONS

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ACHIEVEMENTS AND AWARDS

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CONFERENCES

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PUBLICATIONS AND ABSTRACTS

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Syed Nasir Abbas Bukhari*, Ibrahim Jantan, Vijay H. Masand, Devidas T. Mahajan , Muhammad Sher, M.Naeem-ul-Hassan, Muhammad Wahab Amjad, Oya Unsal Tan. Synthesis of α, β-Unsaturated Carbonyl Based Compounds as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: Characterization, Molecular Modeling, QSAR Studies and Effect Against Amyloid β-Induced Cytotoxicity. European Journal of Medicinal Chemistry. (2014) 83, 355-365.

S.N.A. Bukhari*, I. Jantan, O.U. Tan, M. Sher, N.U. Hassan, H.L. Qin, Biological Activity and Molecular Docking Studies of Curcumin Related alpha, beta- Unsaturated Carbonyl Based Synthetic Compounds as Anticancer Agents and Mushroom Tyrosinase Inhibitors, J Agric Food Chem, 2014, 62 (24), 5538–5547.

S.N.A. Bukhari*, G. Lauro, I. Jantan, G. Bifulco, M.W. Amjad, Pharmacological Evaluation and Docking Studies of α, β-Unsaturated Carbonyl Based Synthetic Compounds as Inhibitors of Secretory Phospholipase A2, Cyclooxygenases, Lipoxygenase and Proinflammatory Cytokines, Bioorg Med Chem, 22 (2014) 4151–4161.

Ahmad W, Kumolosasi E, Jantan I, Bukhari SNA, Jasamai M.(2014), Effects of Novel Diarylpentanoid Analogues of Curcumin on Secretory Phospholipase A2, Cyclooxygenases, Lipoxygenase and Microsomal Prostaglandin E Synthase-1. Chemical Biology & Drug Design. 2014, 83 (6), 670-681.

Bukhari, S. N. A., Tajuddin, Y., Benedict, V. J., Lam, K. W., Jantan, I., Jalil, J. and Jasamai, M. (2013), Synthesis and Evaluation of Chalcone Derivatives as Inhibitors of Neutrophils' Chemotaxis, Phagocytosis and Production of Reactive Oxygen Species. Chemical Biology & Drug Design. 2014, 83 (2), 198-206.

Fatemeh Khaleghia, Ibrahim Jantanb, Laily Bin Dinc, Wan A. Yaacobc, Mohammad A. Khalilzadehd, Syed Nasir Abbas Bukhari, Immunomodulatory effects of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone from Petasites hybridus and its synthesized benzoxazepine derivatives. Journal of Natural Medicines. 2014, 68, (2), 351-357.

Syed Nasir Abbas Bukhari*, Ibrahim Jantan and Malina Jasamai , (2013) Anti-inflammatory trends of 1, 3- Diphenyl-2-propen-1-one derivatives , Mini Rev Med Chem. 2013, 13: 87 - 94.

Syed Nasir Abbas Bukhari*, Malina Jasamai and Ibrahim Jantan,(2012) Synthesis and biological evaluation of chalcone derivatives (Mini review) , Mini Rev Med Chem. 2012, 12: 1394 - 1403.

Syed Nasir Abbas Bukhari*, Malina Jasamai and Ibrahim Jantan, (2013) Methods and catalyst used for chalcone derivatives, Mini Reviews in Organic Chemistry. 2013, 10: 73 - 83.

Syed Nasir Abbas Bukhari*, Scott G.Franzblau, Ibrahim Jantan and Malina Jasamai, (2013) Current prospects of synthetic curcumin analogues and chalcone derivatives against Mycobacterium tuberculosis, Medicinal chemistry. 2013, 9 (7): 897 – 903.

Jantan, I., Bukhari, S. N. A., Lajis, N. H., Abas, F., Wai, L. K. and Jasamai, M. (2012), Effects of diarylpentanoid analogues of curcumin on chemiluminescence and chemotactic activities of phagocytes. Journal of Pharmacy and Pharmacology, 64: 404–412.

Bukhari, S. N. A., Jantan, I., Lajis, N. H., Abas, F., Wai, L. K. and Jasamai, M. (2013), Synthesis and effects of pyrazolines and isoxazoles on the phagocytic chemotaxis and release of reactive oxygen species by zymosan stimulated human neutrophils. Medicinal Chemistry. 9(8):1091-8.

Syed Nasir Abbas Bukhari*, Ibrahim Jantan and Malina Jasamai, (2013) Synthesis and Biological evaluation of curcumin analogues, Journal of Medical Sciences, 13 (7) 501-513.

SNA Bukhari*, W Ahmad, AM Butt, N Ahmad, MWB Amjad, MA Hussain, VH Shah, AR. (2012) Synthesis and evaluation of chalcone analogues and pyrimidines as cyclooxygenase (COX) inhibitors, African Journal of Pharmacy and Pharmacology. 6 (14), 1064-1068.

SNA Bukhari*, W Ahmad, AM Butt, N Ahmad, MWB Amjad, VH Shah, Synthesis and evaluation of chalcone analogues based pyrimidines as Angiotensin converting enzyme inhibitors, Pakistan journal of Biological sciences, 16(21): 1368-1372, 2013.

Bukhari, S. N. A.*, Jantan, I., Lajis, N. H.,and Jasamai, M. (2011), Synthesis and Immunomodulatory effects of curcumin diarylpentanoid analogues. 7th Indochina conference on pharmaceutical sciences, December 1 4- 16, 2011, Bangkok Thailand. PO-PC-08. Page 241.

SN Abbas Bukhari*, Jantan, I., Lajis, N. H., and Jasamai, M. (2012), synthesis and Immunomodulatory properties of synthetic chalcone derivatives. 1st International Postgraduate Conference on Pharmaceutical Sciences (iPoPS) 28th – 30th June 2012, Selangor, Malaysia. Page 53.

*as corresponding author