RESEARCH ACTIVITIES & OUTPUTS

PUSAT PENGIMEJAN DIAGNOSTIK NUKLEARUNIVERSITI PUTRA MALAYSIA

2013-14

RESEARCHACTIVITIES& OUTPUTS

Staff of Pusat Pengimejan Diagnostik Nuklear

2013 - 2014

ANNUAL BOOK 2013-14(Research Activities & Output)

Cetakan Pertama/First Printing, 31.1.2015Hak Cipta/Copyright Pusat Pengimejan Diagnostik Nuklear,

Universiti Putra Malaysia

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terlebih dahulu.

All rights reserved. No parts of this publication may bereproduced or transmitted in any form or by any means,

electronic or mechanical, including photocopy, recording or any information storage and retrieval system, without permission in writing from Publisher.

Diterbitkan di Malaysia/Published in Malaysia by

PUSAT PENGIMEJAN DIAGNOSTIK NUKLEAR

UNIVERSITI PUTRA MALAYSIA43000 SERDANG, SELANGOR

Abdul Jalil Nordin

Fathinul Fikri Ahmad SaadHishar HassanRosli Md Yusof

ISSN: 977-2289-520005

RESEARCH ACTIVITIES & OUTPUT 2013-14iii

The Pusat Pengimejan Diagnostik Nuklear would be 5 years old now, and we are pleased to introduce the 4th issue of the Annual Book 2013/14 in celebration.

It is due to the earnest efforts by our local researchers and collaborators that our agenda in engaging high quality research works and the effort are well solidified and forthcoming.

This book edition offers a valuable documentation on our achievements across the year of 2013/14 which highlights research activities by our researchers and the eminent collaborators nationwide and internationally. With the new state-of-the-art MRI 3.0 Tesla system is in its path of installation to complement the existing the PET-CT system, these exemplary works towards ameliorating research in translational imaging will become more phenomenal in the year to come.

At this juncture, the quantity and quality become the major concerns in every means and ways, we are leaping forward without exclusion of our constant commitment with the related industries and communities in the provision of education.

I thank all the contributing efforts by parties for their exceptional works on behalf of PPDN.

Your endless efforts and continuing support have enabled us to move forward to achieve ‘highcentre of excellence’.

I wish you all the best.

‘ With Knowledge We Serve’

Prof. Dr. Abdul Jalil NordinDirector

Words from the Director

Prof. Dr. Abdul Jalil NordinMD UKM, M Med Rad UMFellowship NMed (Sydney, AUS)Fellowship PET CT (Zurich, SWISS)Preceptorship Cardiac PET (Cleveland, USA)

RESEARCH ACTIVITIES & OUTPUT 2013-14 iv

Associate Council Members

Rosetti ClaudioDirector and Associate ProfessorNuclear Medicine and PET/CT Centre,Ospedale Niguarda Ca’ Granda, Piazza Ospedale Maggiore 3,Milan 20126, Italy

W F Eddie LauDirector of Clinical, PETCentre for Cancer Imaging The Peter Mac Callum Cancer Centre,Univ. of MelbourneAustralia

Prof (M) Dr Abdul Rahman MohamadAdjunct Professor in Nuclear MedicineCentre for Diagnostic Nuclear ImagingFaculty of Medicine & Health SciencesUniversiti Putra Malaysia

Dr Noraini Abdul RahimConsultant RadiologistNational Cancer Institute,Putrajaya, Malaysia

RESEARCH ACTIVITIES & OUTPUT 2013-14v

Associate Council Members

Prof (M) Dr. S.T. SubhaConsultant ENT SurgeonInternational Medical University Malaysia (IMU)

Dr Hairil Rashmizal Abdul RazakSenior LecturerFaculty of Health ScienceUiTM

Dr. Ahmad Fazli Bin Abdul AzizInterventional CardiologistFaculty of Medicine & Health SciencesUniversiti Putra Malaysia

Dr. Ahmad Hisham Bin Abd. RashidOrthopedic SurgeonFaculty of Medicine & Health SciencesUniversiti Putra Malaysia

Assoc. Prof. Dr. M. Iqbal Bin SaripanFaculty of Engineering Universiti Putra Malaysia

RESEARCH ACTIVITIES & OUTPUT 2013-14 vi

Editorial Preface

It is my privilege to welcome you to the 2013/14 annual book of the Pusat Pengimejan Diagnostik Nuklear (PPDN), UPM.

As we are growing with the advancement of the research and education in molecular imaging, the achievement in research agenda and numbers of academia via engagement of the national communities and industries are on the rise.

This 4th issue of the annual book portrays quality efforts by the PPDN staffs and his fellow research collaborators in the substantiation of research outputs towards becoming a centre of excellence.

The editor and his associates are indebted to all parties who have contributed in making this issue a continuous report publication.

Any remaining errors and infelicities are his alone

I wish you all the best.

Sincerely,

Chief Editor

Editorial Team

Dr Fathinul Fikri AS

Chief Editor

Mr. Hishar Hassan

Associate Editor

Mr Rosli Md. Yusuf

Table of Contents

01

11

23

33

National Research Activity

International Research Activity

Research Programmes

Research Reports


2013-14

RESEARCHACTIVITIES& OUTPUTS

RESEARCH ACTIVITIES & OUTPUT 2013-14


NATIONAL RESEARCHACTIVITIES


In its 7th year, the National Conference for Clinical Research is taking the significant step of celebrating the impact clinical research has on healthcare. With the theme Translate and Transform, the conference was aimed at how translating clinical research information transforms healthcare services. The event was also looked at strengthening regulatory and ethics; and ensuring that researchers and industry are aware of the regulations and adhere strictly to them. In the Ministry of Health, the patients are always the priority and their safety is paramount even when clinicians switch to be the researcher.

In the events, 3 PPDN researchers have participated for the poster presentation as detailed below:

Achievements

Poster titles Reseracher

Extrapulmonary tuberculosis infection is an important cause of false positive FDG avidity in PET-CT imaging studies of malignant conditions albeit has potential role in monitoring anti-tuberculosis treatment.

Prof Dr Abdul Jalil Nordin

Value of 18[F] FDG PET-CT and inflammatory markers in malignant tumors

Dr Fathinul Fikri

The value of pretreatment PET-CT in predicting survival in patient with esophageal cancer

Dr Shahrin Samat

National Conference for Clinical Research

RESEARCH ACTIVITIES & OUTPUT 2013-14 3

PET-CT Course II, 13-14th Nov 2014

The Centre had optimize her international collaborators through MOU with Milan-Bicocca University and ASEA-Europe University Network to assist in the final assessment of the candidates in this program.

The course is aimed at doctors who have little hands-on experience in reading PET/CT examinations and provides the technical and clinical basics to successfully start a career in reading PET/CT examinations. It provides knowledge on the basic PET/CT physic, technique and clinical applications in various disease categories. Furthermore, it also provides opportunity for the participants to gain some experience in the technique and hands-on session during the PET/CT examination session. At the end of the programme, the participants were expected to understand the role of FDG-PET/CT imaging in various disease entities with emphasis on oncology

The programme was attended by 8 radiologists/ radiology registrar from Hospital Serdang and Faculty of Medicine and Health Sciences UPM. A total of 10 hours of lectures and 5 hours of hands-on session were acquired to benefit the participants. Among external speaker to the course were, Dr Abdul Rahman Mohamad (President College of radiology Malaysia), Dr Noriah Jamal ( Malaysian Nuclear Agency) and Dr Hairil Rasmizal (UiTM).

Achievement:

• Knowledge transfer programme to the professional community

• Collaboration with industrial players – Siemens Malaysia & Abex Medical System Sdn. Bhd.


The 5th Research University Exhibition, NECTAR, UKM

Universiti Kebangsaan Malaysia (UKM) in collaboration with Kementerian Pendidikan Malaysia (KPM) had organized The 5th Research University Achievement Exhibition on 4th Disember 2014 Dewan Canselor Tun Abdul Razak, UKM, Bangi, Selangor.Theme of the programme was ‘Universiti For Community’ in line with the effort to uphold the national interest towards becoming the regional center of excellent in education. All the RU universities which include Universiti Malaya, Universiti Putra Malaysia, Universiti Sains Malaysia dan Universiti Teknologi Malaysia had participated in the event. Pusat Pengimejan Diagnostik Nuklear was selected to represent UCTC UPM in highlighting its effort in the industrial collaboration on the tripartite benefit impact. In this regard, Siemens Malaysia had given a constant support in

educating the professional via courses hosted by PPDN since 2010. One of those was the PET-CT course which had successfully held for the third consecutive time which had involved participation from the local and regional professionals. The event was officiated by the Minister of Education II.

Participated Researchers:

• Dr Fathinul Fikri Ahmad saad• Ms Salasiah Mustafa• Mr Ismarezzal Ismail

Achievement:

Poster exhibition and tripartite collaboration with Siemens Malaysia


Annual Scientific Meeting, College of Radiology and Korean Radiology Society 20143rd-5th April 2014

Malaysian Congress of Radiology was held on the 3rd to 5th April 2014 at the Putrajaya Marriot Hotel and Spa. The Congress incorporated the 2014 Annual Scientific Meeting and KSR-MCor Friendship symposium. The pre-congress workshops were held on the 3rd and the actual scientific meeting on the 4th and 5th April 2014. Participated Researchers:

• Prof Dr Abdul Jalil Nordin• Dr Fathinul Fikri Ahmad Saad

Achievement:

• National organising member ( Prof Dr Abdul Jalil Nordin)

• Poster presentation (Certified of Merits)


Workshop on Advanced Materials & Nanotechnology 201425-26th Aug 2014

Synopsis of the speech by Prof Dr Abdul Jalil Nordin

“The field of Medical Imaging evolved with many advanced features. The evolution is evident from initial discovery of X-ray in early 1900, adapting new generation of computer system in the 1970s and incorporating digitization technology in the 1990s. The progress of imaging technology then, marked an important milestone achievement in clinical practice placing a major role for medical imaging in routine clinical procedure for diagnostic work up. The fundamental bio-physiology property of each modality is exploited in characterizing normal and diseased tissues . X-ray and sound wave interaction with matters in CT and ultrasound , proton magnetization in MR and in-vivo tissue uptake of isotopes in SPECTS and PET systems to be named a few . Recent imaging technology advancement is geared towards early detection of anatomical and functional tissue alteration especially in cancer imaging. The Computed Tomography (CT)

Magnetic Resonance Imaging (MRI) and Nuclear Imaging systems are most common non invasive modality used in cancer imaging at initial staging and post-treatment monitoring. To increase the clinical value, mono-dality imaging system are now combined , integrating various modalities into a single hybrid system with improved accuracy in cancer imaging . The success story is partly contributed by the discovery of 2-deoxy-2-(18F)fluoro-D-glucose (18F-FDG) , a potential imaging bio-tracer in Positron Emission Tomography (PET) imaging. Farther to this, the recent thera-nostic concept of medical imaging has created a new path in innovating the future role of medical imaging in molecular medicine . Perhaps, the future direction of clinical medical imaging will be directed toward the development of multifunctional nano-medical platforms for targeted imaging or simultaneous diagnosis and therapy including CT and MR where the therapeutic effect of drug delivery can be visualized during personalized therapy”.

Participated Researcher:

• Prof Dr Abdul jalil Nordin

Achievement:

• The evolving clinical role of Medical Imaging (speaker)


My Expo exhibition ,UPM19-21 Julai 2013

Malaysia Innovation Expo (MIExpo 2013) was held on 26th – 28th Sept 2013, banquet hall, UPM. The event theme was Urban Agriculture and Food Security. MIExpo 2013 was a golden opportunity for entrepreneurs and business people to get to know and link up with researchers and academicians and explore possible business and entrepreneurial collaborations. Among the notable inventions and innovations you can expect to see at the exhibition were:

• A rapid diagnostic kit for early detection of acute leptospirosis, a lethal bacterial disease spread by rat urine;

• The novel bifunctional bioactive peptides against cardiovascular diseases generated from palm kernel cake protein;

• A novel procedure for efficient collagen production from jellyfish.

Innovations that were featured highlights embraced the fields of agriculture and food; applied science and engineering; biosystems and biotechnology; business, economy and governance; the environment and energy; forestry and biodiversity; halal science and management; health and well-being; humanity and nation-building; science and materials technology; mathematical sciences; and information technology and communication. Besides the exhibition, there were edu-tourism packages, such as visiting the Museum of Human Anatomy, Museum of Animal Anatomy and the Conservatory Agriculture Park, and the Institute of Bioscience to see a variety of herbaceous plants and others.


• Abdul Jalil Nordin

Achievement:

• Abdul Jalil N, Fathinul Fikri AS Attenuation corrected PET-CT myocardial perfusion using 82Rubidium allow quantification of coronary flow reserve with improve left ventricular function assessment - a preliminary experience: Bronze medal


State-Of-The-Art Multimodality Molecular PET, SPECT, CT And MR Imaging23 September 2014

The seminar was organised with the corporation of the ABEX Medical System. ABEX Medical System had brought in an outstanding speaker; Dr. Greg Mullen whose expertise is well known among the peer colleagues in biological imaging and radiopharmaceuticals from Chemistry/Biology Department, Kings College, London. There were about 60 attendees who made their participation available for the 2 hours talk. Prof Dr Abdul Jalil had also initiated the talk on the general aspect of molecular imaging and the current challenges prior to the Muller’s session.

Participated Researchers:

• PPDN staffs

Achievement:

• Joint-effort scientific collaboration with the ABEX Medical system Intervarsity collaborations


Sabah District Health Screening – UPM Joint Humanitarian Effort With UKMMC-Sabah Nurses Association

The program was held at Kg Kaingarabn, Tambunan, Sabah focusing a minority rural subpopulation who resides in remote area. It was aimed at enhancing the university involvement for the community service via knowledge transfer and providing professional service. There were about 100 people who turned out for the health screening campaign for various health status which include cancer detection, man and women well-being. Approximately 50 people had undergone ultrasound screening and recruitment for research subject based on the provided questionnaire. The questionnaire was sought to enquire the level of education and understanding towards cancer prevention and effects. The effort was also supported by various parties as detailed in the table below to ensure its success. Those include 40 UKM’s medical students and 6 gynaecologist and one urologist from UKM medical centre. .

Achievement:

Contribution & Collaboration

No Industrial partner Contribution

1 IDSMed Sdn Bhd 2 units of ultrasound machine

2 Pusat Kesihatan Universiti, UPM

Malaria prophylaxis

3 UKM medical centre

Medical specialists and medical studets

4 Sabah Nurses asociation

Staff nurses and medical equipment



INTERNATIONAL RESEARCHACTIVITIES


International Workshop on Radiotracers: Production Technology and ApplicationsOrganisation of Islamic Conference Standing Committee on Scientific and Technological Cooperation (COMSTECH) Building Islamabad, Pakistan21 – 23rd October 2013

Workshop targeted to young chemist, physicist, physicians and technologist at the postgraduate level who are either using or intend to use radiotracer techniques in medicine, research or industry. In view of increasing significance of radiotracers in medical diagnosis, industrial process control, materials analysis and study of geophysical and environmental phenomena, it appeared that the workshop had significantly elevated the participants’ inputs. The participants were in limited number, hence the selection criteria was very strict. Upon admission to the workshop, the selected participant received an incentive such as local hospitality and free accommodation by the COMSTECH.


• Hishar Hassan

Achievement:

• Research collaboration: PET Radiopharmaceuticals in Malaysia: Where are we?


Pre Congress Molecular Imaging Tract (ASM CoR)

The workshop was divided into two sessions including highlights on selected topics and hands on session on PETCT workstation The workshop was organized by The Centre for Diagnostic nuclear Imaging University Putra Malaysia and facilitated by 3 local experts from UPM, Loh Guan Lai Hospital and an Expert Mission from International Atomic Energy Agency (IAEA) Senior Consultant in Nuclear Medicine Prof Dr Jan Pruim from The University Medical Centre Groningen (UMCG), The Netherlands.

There were about 15 attendees who participated in the 4 hours lectures and the hands-on sessions.

Highlights on techniques, role of PET-CT in breast cancer, oncology, infection and non FDG PETCT indications were delivered during the lecture session. There were 5 workstations provided by Siemens for the hands on session. Cases were uploaded from UPM and UMCG. Prof Dr Jan Pruim gave a lecture on “The role of PETCT in cardiovascular imaging” during a lunch symposium.

Achievement:

• Promotion of the academic experts in molecular imaging

• Industrial collaborative efforts – College of radiology Malaysia, IAEA (Malaysia) & Siemens Malaysia


ASEA UNINET 17-21 Feb 2013

In 1994, ASEA UNINET was represented by 25 Austrian universities, Thailand, Indonesia and Vietnam. Since 1997, more universities counterparts have been engaging in this networks which include Republic Czech, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Netherlands, Philippines, Sweden, Spain, United Kingdom. In 2013, Malaysia was selected to play host the 13th Plenary meeting which was successfully been held in the Marriott Hotel, Putrajaya from 17-21 Feb 2013. Prof Dr Abdul Jalil Nordin was elected for the coveted presidency seat from 2013-14 session. About 300 over national and international delegates had attended the 5-day meeting .

Achievement:

• Prof Dr Abdul Jalil Nordin• International & National Collaboration• ASEA-UNINET Plenary book (ISBN: 978-

967-11361-1-9)• National coordinators

• MoU Innsbruck• Officiation of a PET-CT book by Prof Dr

Abdul Jalil Nordin


The Congress offered the opportunity for researchers, academicians, technologist and clinicians to get update on the latest developments, technical advances and on-going exciting researches at the largest diagnostic imaging congress in the United Kingdom. There were free ‘education on stands’ as well, conducted by the leading industries in diagnostic imaging as an initiatives for getting closer to the end user. Overall, the Congress succeeded in conveying scientific and recent technology updates to the delegates.


• Hishar Hassan

Achievement:

• Hishar H, Fathinul Fikri A.S, Salasiah M, Noramaliza Mohd N, Abdul Jalil N. Investigation on the influence of dose minimization management on the PET image quality – proceeding and publication in Radiography 2014; 20: 65-69

• Hishar H, Fathinul Fikri A.S, Salasiah M, Noramaliza Mohd N, Abdul Jalil N. Investigation on the influence of dose minimization management on the PET image quality – Top Ten Research Posters by Jury.

United Kingdom Radiological Congress 2013 (UKRC 2013), “Essential Imaging”ACC LiverpoolLiverpool, United Kingdom10 – 12th June 2013


The scientific visit was fully funded by the International Atomic Energy Agency (IAEA) through Technical Cooperation Project under MAL6021: Improving human resource skills in hybrid imaging. The participant, Hishar Hassan had attended a two weeks attachment in University of Milano Bicocca and San Raffaele Hospital in Milan intensively. Over the course of two weeks, he intensively gained exposures on the training focussing on radiolabelling and quality controls procedures for routine and experimental radiopharmaceuticals labelled with Fluorine-18 and Carbon-11. The training also includes the preclinical animal imaging. He also visited Niguarda Hospital in Milan and

San Gerardo Hospital in Monza to observe the routine and current research conducted in cyclotron and radiopharmaceuticals facility and also the local practice.


• Hishar Hassan

Achievement:

• Potential international collaboration in research activity

• Reviewer for manuscript writing

Scientific Visit to University of Milano Bicocca & San Raffaele Hospital Milan, Italy15 – 26th September 2014


The Agency also hosted a side-event in Bali on how the IAEA can aid Member States in the development of their own peaceful nuclear power programme entitled Nuclear Power Prospects and IAEA Assistance for Interested Developing Countries, the presentation touched upon nuclear programme implementation for States interested in launching a nuclear power programme. Indonesia´s National Nuclear Energy Agency (BATAN) also participated in the side event and gave a presentation on the country´s developing nuclear power programme. Over 120 people attended the IAEA event. The Bali talks represent the first in a series of meetings planned to take place over the next two years. The discussions were the first steps that parties hope will lead to a follow-up agreement to the Kyoto Protocol (which includes emission reduction obligations for industrialized countries), and many of the more contentious issues are expected to be worked through later in the process.

35 participants representing 77 Member States and 16 organizations attended the Conference, which was held at the World Conference Center, Bonn (the former federal government Plenary Chamber).


• Prof Dr Abdul Jalil attended the meeting as a mission to promote and expand the molecular imaging agenda pioneered by PPDN in Malaysia.

Achievement:

• International Research Networking

15 IAEA Countries Evaluate Application of RadiotracersMay 2014

The Congress is an annual event and consists of a three-day multidisciplinary scientific and technical focused on the medical imaging. It offers the opportunity for researchers, academicians, technologist and clinicians to get update on the latest developments, technical advances and on-going exciting researches at the largest diagnostic imaging congress in the United Kingdom. Overall, the Congress succeeded in conveying scientific and recent technology updates to the delegates.


• Hishar Hassan

Achievement:

• Hishar H, Mohd Hafizi M, Fathinul Fikri A.S, Salasiah M, Abdul Jalil N. Patient dose management: Should we move to lean body mass? – proceeding and poster presentation

United Kingdom Radiological Congress 2014 (UKRC 2014), “Medical Imaging”Manchester Central Convention ComplexManchester, United Kingdom9 – 11th June 2014


Diagnostic imaging study using integrated whole body 18F-FDG PETCT can be optimized to demonstrate atherosclerotic plagues in medium and large size arteries with significant CT correlation in patients with high risk factor developing cardiovascular disease. This study provide a possible insight in identifying patients for further cardiovascular assessment .


• Prof Dr Abdul Jalil Nordin

Achievement:

• AJ. Nordin1, S. Shahruddin1, F. F. Ahmad Saad, N. Abdul Rahim, H. Hassan, S. Mustafa1; Vascular Plagues Assessment using 18FFluorodeoxyglucose (FDG) Positron Emission Tomography (PET) and Computed Tomography (CT) during contemporaneous imaging acquisition: a preliminary study DOI: 10.1594/ecr2014/C-2036

European Society of Radiology (2014)


The Rector of the University of Ioannina, Prof. Albanis and Vice-Chairman of the University Council Ioannina, Prof. Nakos as well as the ASEA-UNINET Chairman, Prof. Tjoa open the National Coordinators’ Meeting in Ioannina, Greece. After 2001 the University of Ioannina hosts the second time a National Coordinators’ Meeting. Prof. Tjoa thanks the University of Ioannina and its staff for the hospitality and the organization of the National Coordinators’ Meeting. The University of Ioannina represents one of the major players of ASEA-UNINET and hosts the second time after 2001 a National Coordinators’ Meeting. During the meeting new

innovative ideas should be collected, therefore he is looking forward to a lot of brainstorming and interesting discussions.


• Prof. Dr Abdul Jalil Nordin

Achievement:

• National Coordinators agree on founding a Linked In group to improve the conversation between meetings.

ASEA-UNINET National Coordinators’ Meeting Ioannina, Greece September, 8. – 12. 2013


Utility of PET/CT has clinical value in prognostication of NSCLC by diagnosing metabolically active disease which can be missed on conventional CT scans. PET/CT is sensitive for the early detection of resistance to EGFR inhibitor treatment in NSCLC and can help to tailor the treatment accordingly for individual patients. Therefore, we recommend patients who undergo targeted therapy to be followed up with PET/CT imaging for optimization of individualized treatment.


• Dr Subha Priya

Achievement:

• Best oral presenter.

The 13th annual course of our Society will focus on practical problem solving in cancer patients through interactive teaching and the fostering of active learning. State of the art and novel imaging techniques will be highlighted. The course will be held at The Royal York Hotel. There were 7 Plenary sessions encompassing various topic in oncology imaging which include; New clinical developments in oncology, Dual energy and low dose CT techniques, Contrast agent use in oncological imaging and 8 Interactive workshop sessions: Multiple myeloma, Head and neck tumours, Pancreatic carcinoma: small lesions and mimic, Gynaecological malignancies: adnexal mass characterisation &Diffusion weighted and diffusion tensor imaging in pediatric neuroimaging.


• Dr Fathinul Fikri Ahmad Saad

Achievement:

• Fathinul F. Value of 18[F] FDG PET-CT and inflammatory markers in malignant tumours –proceeding and publication in the Cancer imaging Journal (IF ; 1.5) .

• Fathinul Fikri AS, Abdul Jalil N. Potential of 82Rb PET-CT as an angiogenesis marker in evaluating tumour aggressiveness- Poster exhibition

22nd Annual Scientific Meeting of Hong Kong College of RadiologistS. Suppiah, AJ Nordin, FF Ahmad Saad NH Mohad Azmi Non small cell lung carcinoma with emerging resistance to epidermal growth factor receptor inhibitors (EFGR) Treatment: Can 18 FDG PET/CT help?

13th Annual meeting and teaching, International Cancer Imaging Society York, United Kingdom. 30 Sep -2 Oct 2013


The 14th annual course of our Society had focused on practically orientated education of cancer imaging through interactive teaching and the fostering of active learning. Multidisciplinary work, practicing state-of-the-art and novel imaging techniques were highlighted in cooperation with the European Society of Oncologic Imaging and the European Association of Nuclear Medicine. The course was held at “Neue Universität” (New University) in Heidelberg, Germany Cancer hallmarks. The participants were furnished with ever changing theme in biology of cancer which included the understanding the biologic principles, biology of tumor invasion and metastases. Cancer imaging in the era of precision treatment: present and future, Beyond the image: sense and non-sense of imaging biomarkers and PET/

14th Annual meeting and teaching, International Cancer Imaging Society Heidelbergh. Germany9-11th Oct 2014

MR as tools for “precision medicine” There were 3 Plenary sessions on the global challenges of cancer imaging, perspective from different parts of the world MDT-Session and the management of prostate cancer patients in the borderland between intermediate and high risk

Achievement :

• Published abstract in Cancer Imaging Journal (Scopus, IF 1.5)

• Fathinul Fikri A S, Abdul Jalil Nordin, Chemotherapy Response Evaluation in Metastatic Non-Small Lung Carcinoma (NSCLC) with 18F- FDG PET/CT and CT Scan.


This scientific visit was fully sponsored by IAEA for the MS1410 (TC Project: Improving Human Resource Skills in Hybrid Imaging). Rosli Md Yusof had attended a 2-week attachment in the PET-CT and MRI unit (SNUH). Various programme which included the hands-on patient management for PET-CT and MRI-PET and scanning techniques were exposed to him. The importance of the onsite training was to enhance interpersonal skill in handling patients undergoing MRI-PET given this modality is not available in our country. He was also visited the cyclotron laboratory and observed the process of radiopharmaceutical productions of various PET tracers.

Participated Personnel:

• Rosli Md Yusof

Achievement:

• International collaboration in future hands-on course

• Gained new technique in MRI-PET study

The essentials of PET-CT in oncology was held in Bangkok in November 2014. The workshop was sponsored by SCHMIDT BioMed Tech. There were representative from other countries i.e Hong Kong, Singapore, Australia who participated in a week-stint event which had emphasized on PET/CT in oncology. Participated Researcher:

• Ammar Saifuddin Ismail

Achievement:

• Enable new knowledge and skill gaining

Scientific Visit to Department of Nuclear Medicine, Seoul National University Hospital (SNUH), South Korea 6 - 17 Oct 2014

Essentials of PET/CT in Oncology” Bangkok, Thailand November 2014



RESEARCHPROGRAMME


In the past decades, we have witnessed the importance of non-

communicable diseases including coronary artery diseases,

malignancy and cerebro-vascular diseases as the main cause of death

in Malaysian hospitals. Molecular imaging is a new field in medicine

characterizing, and quantifying the biological processes at the cellular

and subcellular levels within intact living organisms. The field exploits

specific molecular probes as the source of image contrast where it

provides the imaging signal in almost all molecular imaging assays.

The development, validation, and application of this novel imaging

technique in living subjects should further enhance our understanding

of disease mechanisms and go hand in hand with targeted personalised

therapy. The findings can be correlated with gene expressions and the

discovery of novel biomarkers with potential utilization in drug discovery.

MOLECULAR IMAGING (HWB 07)


RESEARCH GROUP: Bioinformatic and Genetic

MicroRNAs (miRNAs)

The identification of new biomarkers for early detection of highly recurrent head and neck cancer is urgently needed. MicroRNAs (miRNAs) are small and non-coding RNAs that regulate cancer-related gene expression, such as tumor protein 53 (TP53) gene expression. This study was carried out to analyze TP53 gene expression using real-time PCR and to determine changes in intracellular p53 level by flow cytometry after downregulation of miRNA-181a miRNA inhibitor in the FaDu cell line. TP53 gene expression showed a 3-fold increment and the p53 protein level was also increased in the miRNA-181a-treated cells. In conclusion, miRNA-181a binds to the TP53 gene and inhibits its expression, decreasing the synthesis of p53.

Achievements

Analysis of TP53 gene expression and p53 level of human hypopharyngeal FaDu (HTB-43) head and neck cancer cell line after microRNA-181a inhibition

Y K CheahFaculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Selangor, MalaysiaGenet Mol Res 13:1679-83. 2014

Researcher Profile:Assoc. Prof Dr Cheah Yoke KqueenSpecialization : Bioinformatics and Genetic Field of interest : Genetic Engineering and Molecular Biology

Collaborator Profile:Dr Tiffany Ng Shi Yeen


RESEARCH GROUP: Oncology- Breast cancer (NET)

Synopsis:

Researchers found links between choline intake and several cancer developments. The level of choline in human breast cancer cells was found to be markedly higher than in normal human mammary epithelial cells..18F-fluorodeoxyglucose (FDG) is a glucose analogue that enables non-invasive imaging of glycolytic metabolism. The role of FDG PET for evaluation of therapeutic response of breast cancer is well known despite some of the histological type which failed to express the positive signaling on the FDG tracer. Total reliance on a single tracer approach may hamper diagnostic accuracy of breast cancer detection. These very real limitations of FDG used in the molecular imaging technique have enticed the search for alternative radiotracers which signal different biological disease process.

Grants:

FRGS (RM 105000)

Achievements:

National collaboration in scientific research

Researcher Profile:Dr Fathinul Fikri Ahmad SaadSpecialization : Radiologist Field of interest : Oncology Imaging

Collaborator Profile:AP Dr. Shahrun Niza Abdullah SuhaimiSpecialization : MBBS ( Malaya), M. Surgery UKMAM ( Malaysia )Field of interest : Endocrine Surgery ( Tokyo )


RESEARCH PROGRAMME: Cyclotron & Radiopharmaceuticals

Radiosynthesis of the PET-Tracer Fluorine-18 Labeled Choline: Towards an Early and Accurate Management of Choline Up-Regulated Cancers

To date neither 18F-Fluoromethylcholine (18F-FCH) nor 18F-Fluoroethylcholine (18F-FECH) are synthesized commercially in Malaysia, hence become a limiting factor for management of choline up-regulated cancers (i.e. prostate cancer) in PET. Thus, investigation on the ability to synthesize a reliable with good radiochemical yields (RCY) and short synthesis time for 18F-FCH and 18F-FECH by using a commercial synthesizer (General Electric TRACERlab FX F-N) is sought after. This study will adapt the Kryza et al., (2008) method in GE TRACERlab MX module and seek to investigate purification method; solid phase extraction (SPE) or semi-preparative high performance liquid chromatography (HPLC) that would yield a high RCY. The primary objective is to synthesize a reliable with good RCY and short synthesis time of 18F-FCH using a GE TRACERlab MX module, for safe human administration. Meanwhile, the secondary objective is to present an improve and comprehensive quality control program for 18F-FCH tracer since no monograph is currently available for radiolabeled choline. Study also aims to establish the pattern of in-vivo 18F-FCH distribution in human and yet to discover the association of the SUV uptake of 18F-FCH in various cancers.

Achievements

Hishar, H.; FathinulFikri, A. S.; Salasiah, M.; Noramaliza, M. N.; Abdul Jalil, N.AIP Conference Proceedings, Volume 1528 (1) American Institute of Physics

Hishar Hassan, Fathinul Fikri Ahmad Saad, Salasiah Mustafa, Noramaliza Mohd Noor, Abdul Jalil Nordin. Investigation on the influence of dose minimization management on the PET image quality. Radiography 2014; 20: 65-69 (SCOPUS)

Researcher Profile:Muhamad Hishar HassanSpecialization : Science Physic in PET-CT and cyclotron

Collaborator Profile:Prof Dr Abdul Jalil NordinSpecialization : Radiology & Nuclear Medicine Field of Interest : Molecular Imaging


RESEARCH PROGRAMME: Physic & Radiation Protection

Molecular Imaging - Standardization Operating Procedure For 18F-FDG PET In Malaysia: Comparable Studies In Pair-Centre Trials.

In the early development of protocols for standardization and quantification of FDG whole body PET studies approached by The Netherlands, the studies were rather complicated to be carried out. At that moment, The Netherlands need a great deal of work with all participants of multi-center trials. Then, The Netherlands succeeded to develop the protocols for standardization to be followed. From those studies, Japan followed the step of The Netherlands for standardization the PET imaging modality. Therefore, there are already the trial studies in Europe (The Netherlands) and Asian (Japan). Significant to those studies, this study research inspired to develop the protocols for PET imaging modality standardization for Malaysia which can represent the Southeast

Researcher Profile:Mohd. Hafiz HanafiSpecialization : Science Physic

Collaborator Profile:Prof. Dr Jan PriumUniversity of Groningen, Netherland Specialization: Nuclear Medicine Physician/Professor of Medical Imaging Working Experience : 15 years Field of interest : Nuclear Medicine

Dr Fathinul Fikri Ahmad SaadSpecialization: Radiology&Nuclearmedicine (PET-CT)Working Experience : 15 years Field of interest : Oncology Imaging

Asia for future studies. In addition, there are no published papers or guidelines regarding standardization in Malaysia to be the reference for plotting the methodology in this study.

Achievements:

Scientific collaboration with national institute partner (Beacon Medical Center) and the Univ. of Gronigen


RESEARCH PROGRAMME: Biomedical Engineering -Neurology

Automatic Classification of Alzheimer Disease (AD) based on PET/CT Brain Imaging

Awareness of dementia-related diseases is growing due to the increasing reported cases around the globeparticularly for Alzheimer disease (AD).Dementia refers to the brain disorders which cause the declination of cognitive function of individuals. In other words, dementia reflects the deterioration of the brain’s intelligence and may affect the individual’s daily routines and activities. It is not a disease itself, however, refers to several signs and symptoms which relate to several diseases. The common early sign of dementia is memory loss. Other brain functions that may be affected are the ability to process thought, language, judgment and behavior. The prevalence of dementia increases with age. However, several normal aging symptoms are not necessarily indicates the presence of dementia. Dementing process in AD is progressive and irreversible. However, early diagnosis and treatment are of importance due to the ability to stagnant and slow the progression

Grants

Grants GP-IBT/2-13/9409900: RM 199200

Achievements

M.Iqbal Saripan, Wira Hidayat Mohd Saad, Suhairul Hashim, Ahmad Taufek Abdul Rahman, Kevin Wells and David Andrew Bradley, Analysis of Photon Scattering Trends for Material Classification using Artificial Neural Network Models, IEEE Transactions on Nuclear Science, Vol. 60, No. 2, April 2013, pp515-518

Researcher Profile:Siti Aishah Abdul Aziz Universiti Putra Malaysia Field of interest : Science Physic

Collaborator Profile:Assoc. Prof. Dr Iqbal SaripanSpecialization : Biomedical Engineering Field of interest : Computer & Electronics


RESEARCH PROGRAMME: Physic

Intravenous contrast-enhanced 18F-FDG PET/CT scanning protocol in cancer imaging

To evaluate the effect of intravenous contrast media during integrated Positron Emission Tomography Computed Tomography (PET/CT) using fluorine-18 fluorodeoxyglucose (18F-FDG) as tracer in cancer imaging.

Achievements:

Hafizi M, Abdul Jalil N, Fathinul Fikri AS. The value of fluorine-18 fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in evaluating malignant tumor: A revised maximum standardized uptake value in highly aggressive tumor. 2nd Annual International Conference on Advance in Cancer Clinical Research (ACMR 2014). 27th-28thOctober 2014, Singapore

Hafizi M, Abdul Jalil N, Fathinul Fikri AS. The effect of contrast-enhanced Computed To-mography in cancer imaging using whole body Positron Emission Tomography/Computed To-mography. 2nd Annual International Conference on Advance in Cancer Clinical Research11 /2(ACMR 2014). 27th-28th October 2014, Sin-gapore

Researcher Profile:Mohd Hafizi MuhamadSpecialization : Molecular Medicine

Collaborator Profile:Prof Dr Abdul Jalil NordinSpecialization : Radiology & Nuclear MedicineField of interest : Molecular Imaging


RESEARCH PROGRAMME: Cardiology (MYOPET)

QUANTIFYING 2-[18F] FLUORO-2-DEOXY-D-GLUCOSE (18F-FDG) MYOCARDIAL UPTAKE IN HIGH FATTY ACID ENVIRONMENT THROUGH ORAL SUPPLEMENT DURING PET/CT ASSESSMENTACID

Several treatment options available for CAD include medications and/or operation and/or cardiac stem cell therapy. These treatment options are very expensive and require accurate verification on which patients needs to go for any one of these options. PET/CT is a hybrid imaging modality, where it is an integration of PET and CT technology. PET/CT has been around in the year 2000 and its utilization in cardiovascular imaging (CVI) is increasing. It has been proven to improve the accuracy in stratifying patients in comparison to other conventional imaging modalities. Malaysia is one the biggest countries in the world that produces palm oil. It accounts for 39% of world palm oil production and 44% of world exports. Being one of the biggest producers and exporters of palm oil and palm oil products, Malaysia has an important role in fulfilling the needs for oils and fats sustainably. Since palm oil can be found abundantly in Malaysia, it has been widely utilized for numerous purposes. This natural product produces no side effects to the consumers. Therefore, this study explores the effect of myocardial uptake of FDG in high fatty acid environment through

Researcher Profile:Prof Dr Abdul Jalil NordinSpecialization : Radiology & Nuclear MedicineField of interest : Molecular Imaging

Collaborator Profile:Mohamad Nazmi NordinMolecular Medicine

oral supplements using TOCOTRIENOL during 18F-FDG PET/CT study. It is a proof of concept where we can further investigate the role of Tocotrienol as a tracer targeting at myocardial metabolism using fatty acid pathway.

Achievements:

Abdul Jalil et al. Reversed Perfusion During Myocardial Cold Pressor Test : a quantifiable parameter predicting endothelial dysfunction in Chronic Diabetes Mellitus and Hyperten-sion using 82Rubidium PETCT. ACNM Annual Meeting. Grand Hyatt San Antonio on January 22-25, 2015- accepted abstract


Detection of Alzheimer’s Disease in 18F-FDG PET/CT using two metabolic pattern

Molecular imaging 18f-fdg pet-ct can be used to detect raised metabolism of vascular plaque for early recognition of high risk patient in developing thromboembolic vascular diseases such as coronary artery disease,peripheral arterial disease and cerebrovascular diseases

Grants Scheme

Geran Putra

Achievements

Mohd Hafrizal Azmi, Fakhrul Zaman Rokhani, Raja Syamsul Azmir Raja Abdullah and M. Iqbal Saripan. Improving the quality of pigskin leather texture images using enhanced image processing. Scientific Research and Essays Vol. 7(12), pp. 1304-1311, 30 March, 2012

Researcher Profile:Assoc. Prof. Dr Iqbal SaripanSpecialization : Bioingineering & ComputerField of interest : Biomolecular Engineering

Collaborator Profile:Mohd Hafrizal Bin AzmiSpecialization : Computer & Communication Systems Engineering



RESEARCHREPORTS


RESEARCH ACTIVITIES 2012

NATIONAL AND INTERNATIONAL RESEARCH COLLABORATION WITH (MOU)

No Institution Since 1 University of Innsbruck 20132 Beacon Medical Centre 20143 University of Brescia 2014

DISTRIBUTION OF PATIENT UNDERWENT PET-CT (2010-2014)

Bar chart shows the distribution of the PET-CT cases throughout 5 years since 2010.

There has been a remarkable increase in the number of patient underwent PET-CT in 2014 after a fluctuant performances in the previous years since 2010. Nevertheless, the major contributors to the escalated referrals are from the non-research subjects which account for more than 90% of the total referrals in 2013-2014.

2010

Year

Research Patient Paid Patient

No

. of

Pat

ient

s

0

20

40

60

80

100

120

140

160 153

21

48

105 102

88

7

67

5

162180

2011 2012 2013 2014


RESEARCH ACTIVITIES 2012

NO OF HOSPITAL REFFERALS 2010-14

Hospital 2010 2011 2012 2013 2014 UPM 21 7 35 7 14 Hos.Serdang 72 38 21 21 17 IPR 6 0 0 0 0 HKL 0 4 4 3 0 HTJ Seremban 7 9 1 0 0 Hos.Ampang 3 3 1 4 0 Hos.Putrajaya 19 18 7 0 99 Hos.Sg Buloh 1 0 0 0 1 Hos.Selayang 1 0 1 1 1 Hos.Kajang 3 0 0 0 0 Hos.Melaka 1 0 0 0 0 Hospital Umum Sarawak 0 0 0 0 1 PPUM 25 24 13 15 5 PPUKM 7 4 2 0 0 CUCMS 0 0 2 0 0 KPJ Damansara 1 0 1 0 0 KPJ Kajang 0 0 0 1 KPJ Seremban 0 1 0 0 0 Gleaneagles Intan Medical Centre 2 2 0 0 0 Beacon International Specialist Centre Sdn Bhd

1 1 1 0 0

Hospital Pantai 1 1 15 7 4 Sunway Medical Centre 0 0 0 1 0 Columbia Asia 0 0 0 1 0 Sime Darby 0 0 0 0 1 The Light Medical Services 0 2 0 0 0 NR Pusat Diagnostik 0 2 0 0 0 Mahkota Medical Centre 0 1 0 0 0 Hospital Damai 0 2 0 0 0 HUSM 0 4 0 20 1 Others 0 2 75 0 0 TOTAL 171 125 179 80 145


RESEARCH GRANTS 2010-2011

AMOUNT OF THE ON-GOING RESEARCH GRANTS (2013-14)

Grant Title Project/Ref Code Amount (RM) StatusERGS Fatty acid metabolism of the

myocardium : exploring its pathway using palmitic acid and saturated fatty acid

ERGS/1/2013/SKK09/UPM/01/2

120 000 On -going

FRGS Ascertaining the value of the dual tracers signaling in breast cancer

04-01-14-1494-FR 103 000 On going

RUGS The clinical value of multimodality imaging for detecting occult metastatic diseases in ovarian malignancy.

04.02-12-1755RU 108 000 On going

RUGS Clinical value of intravenous contrast during whole body 18F-FDG PET CT imaging in cancer patient

04-02-12-1748RU 15 000 Completed

RUGS Establishing the clinical role of multi-modality imaging in diagnosis of Alzheimer’s disease - pilot study

04-02-12-1749RU 30 000 Completed

RUGS Optimization of 18F-FDG dose adjusted for whole-body PET oncology examination in CDNI of UPM

04-02-12-1750RU 30 000 Completed

RUGS Variation in radiation dosimetry for workers in multi-modality imaging PET CT facility

04-02-12-1751RU 30 000 Completed


RESEARCH OUTPUTS 2010-2014

NUMBER OF PUBLICATION (2010-2014)

RESEARCH AWARDS (2009- 2012)

Year Title Event / Award2013 Fathinul Fikri AS, Abdul Jalil Nordin, Nuhafizah

Mokhtarudin, Hemalata, W F Eddie Lau . 18[F] FDG-PET/CT is a useful molecular marker in evaluating thymoma aggressiveness.

Exhibition at the Malaysian Trade Exhibition (MTE), Feb 2013, PWTC Oral Presentation (Bronze Medal)

2013 Muhammad Hishar Hassan, Fathinul Fikri, Abdul jalil Nordin.Investigation of the influence of dose minimization management on the PET image quality.

United Kingdom Radiological Congress 2013, Liverpool, United Kingdom Selected as the best top 10 poster for Journal Publication

2013 Abdul Jalil N, Fathinul Fikri AS Attenuation corrected PET-CT myocardial perfusion using 82Rubidium allow quantification of coronary flow reserve with improve left ventricular function assessment - a preliminary experience

MyExpo UPM 2013

2014 Fathinul Fikri AS, Abdul Jalil N. Potential of 82Rb PET-CT as an angiogenesis marker in evaluating tumour aggressiveness. CoR 2014

Annual Scientific Meeting of the College of Radiology : Poster Presentation (Merits of Awards)

2014 S. Suppiah, AJ Nordin, FF Ahmad Saad NH Mohad AzmiNon small cell lung carcinoma with emerging resistance to epidermal growth factor receptor inhibitors(EFGR) Treatment: Can 18 FDG PET/CT help ?

22nd Annual Scientific Meeting of Hong Kong College of Radiologist (Best Oral)

2010-11

Journal Proceeding

10

1211

25

11

15

7

20

2011-12 2012-13 2013-14


RESEARCH OUTPUTS 2010-2011

PROFESSIONAL CONSULTANCY SERVICE

No Scientific/Peer Group Organisation Designation Year1 British Journal of Radiology1 Associate Editor 20122 Journal of Medical Diagnostic Method Special issues in

Molecular Diagnostic and Critical Medicine2Editor 2012

3 Journal of Medical Patent2 Editor 20134 Journal of Molecular Biology & Molecular Medicine2 Editor 2014

1 Prof Dr Abdul Jalil Nordin2 Dr Fathinul Fikri

POST GRADUATED STUDENTS

No Name Internship GraduateMaster in Science (UPM)

1 Mohd Hafizi Mahmud GS30696 20162 Dr Shazreen Shaharudin GS28603 20133 Kamarul Amin (UiTM) 20134 Mohd Nazmi Nordin 2016

PhD1 Siti Aishah GS39467 20172 Hafrizal 2018


RESEARCH OUTPUTS 2013/14

MANUSCRIPTS

Title JournalFathinul Fikri AS. AJ Nordin, . M.Z.Immeran, Ahmad Saad F N. Application of PET-CT in oncology :

Journal of Pertanika. In press. Scopus

AS Fathinul Fikri,AJ Nordin,YQ Cheah,FN Ahmad Saad,. 18[F] FDG PET/CT in oncology: a ‘sign of the times’ in multimodality imaging. 2013 International Conference on Frontiers of Environment, Energy and Bioscience (ICFEEB 2013) . Beijing, China, October 24-25, 2013.

DEStech Publications, Chapter in book. iSBN: 978-1-60595-133-1

Syafinaz Amin Nordin, Faridah Idris, Malina Osman, Rukman Awang Hamat, Fadzillah Ghazali, Fathinul AS. Refusing Diphteria vaccine; 2014. a case report.

The Medical Journal of Malaysia. 2013. 68 (5), 435-436. Scopus

Hishar H, Fathinul Fikri A.S, Salasiah M, Noramaliza Mohd N, Abdul Jalil N. Impact of Total Activity Variation in 18F-FDG Injected with the Overall PET Image Quality in Oncology Patients” American Institute of Physics (AIP) Conference Proceedings.

American Institute of Physics (AIP) Conference Proceedings (2013). 1528, 2013, Pages 412-416 (Scopus/ISI).

Salasiah M, Hishar H, Fathinul Fikri A.S, Noramaliza Mohd N, Abdul Jalil N. Radiation Dose To Radiosensitive Organs In Pet Myocardial Perfusion Examination Using Versatile Optical Fibres. SPIE 8775,

Micro-structured and Specialty Optical Fibres II, 8775, 2013, Article number 87750U. doi:10.1117/12.2017113SPIE Conference Rep. Chezk (2013) ISI

Shazreen Shaharuddin, Ahmad Zaid Fattah Azman, Katiza Haida Ali, Abdul Latif Mohamad, FathinulFikri Ahmad Saad, Abdul Jalil Nordin Vulnerable plaque detection: The role of 18-fluorine fluorodeoxyglucose in identifying high risk patients

Alexandria Medical Journal. 2013. 49(3). Embargo.

Fathinul Fikri Ahmad Saad, A Kroiss, Zf Ahmad, H Zanariah, Wfe Lau, C Uprimny, E Donnemiller, D Kendler, Aj Nordin, Ij Virgolini. Localization and prediction of malignant potential in recurrent pheochromocytoma/paraganglioma (PCC/PGL) using 18F-FDG PET/CT.

Acta Radiologica, 2013. 55( 5): 631-640(Scopus/ISI)

Hafizi Mahmud, Fathinul Fikri Ahmad Saad. Estimation of patient radiation dose from whole body 18F-FDG PET/CT examination in cancer imaging: A preliminary study .

Journal of Physics Conference Series, IOP, UK. : accepted. (ISI)

Fathinul Fikri Ahmad Saad, Cheah Yoke Kqueen, Hishar Hassan, Salasiah Mustafa, Abdul Jalil Nordin. 18[F] FDG-PET/CT Is A Useful Molecular Marker In Cancer Biology..

The Research and Biology of Cancer. iConcept Press. ISBN: 978-14775549-9-9.

Fathinul Fikri Ahmad Saad, Mohd. Nazri, Abdul Jalil Nordin. . Nuclear Medicine Imaging in spine injury. Imaging in Nuclear Medicine

(Chapter in book). Springer Verlag. accepted

Hishar H, Fathinul Fikri A.S, Noramaliza Mohd N, Abdul Jalil N. Investigation on the influence of dose minimisation management on the PET image quality

Radiography. 2014. 20(1) ; 65-69

Hishar Hassan, Fathinul Fikri Ahmad Saad, Salasiah Mustafa, Noramaliza Mohd Noor, Abdul Jalil Nordin. Investigation on the Influence of Dose Minimization Management on the PET Image Quality.

United Kingdom Radiological Congress 2013, Liverpool, United Kingdom


PROCEEDING/POSTER 2013/14

Title Learned SocietySalasiah M, Hishar H, Fathinul Fikri A.S, Noramaliza Mohd N, Abdul Jalil N. Radiation Dose To Radiosensitive Organs In Pet Myocardial Perfusion Examination Using Versatile Optical Fibres. SPIE 8775, Micro-structured and Specialty Optical Fibres II, 87750U

SPIE Conference Rep. Chezk (2013)

Hishar, H.; FathinulFikri, A. S.; Salasiah, M.; Noramaliza, M. N.; Abdul Jalil, N. -AIP Conference Proceedings, Volume 1528 (1)

American Institute of Physics – May 8, 2013

Hishar Hassan, Fathinul Fikri Ahmad Saad, Salasiah Mustafa, Noramaliza Mohd Noor, Abdul Jalil Nordin. Investigation on the influence of waiting time period on the PET image quality.

CoR/MOS/MSR Annual Scientific Meeting 2013

Fathinul F, Hafizi Mohamad, AJ Nordin.The effect of contrast-enhanced Computed Tomography in cancer imaging using whole body Positron Emission Tomography/Computed Tomography.

1st Annual on International Medical Cancer Research (ACMR 2013) Singapore.

Fathinul Fikri AS. AJ Nordin, . M.Z.Immeran, Ahmad Saad F N. Experience with 18[F] FDG PET/CT in oncology : a ‘sign of the times’ in molecular imaging.

International Conference on Frontiers of Environment, Energy and Bioscience. Beijing, China. 2013

Fathinul F. Value of 18[F] FDG PET-CT and inflammatory markers in malignant tumours.

13thAnnual meeting and teaching, International Cancer Imaging Society, York. United Kingdom. 30Sept. -2 Oct 2013

AS Fathinul Fikri . Cardiovascular adaptation to spaceflight; a need for ‘pulse wave system’ integration in the hypergravity pull study.

OMICS. Philidelphia, USA.2014

Fathinul Fikri AS, Abdul Jalil Nordin, Nuhafizah Mokhtarudin, Hemalata, W F Eddie Lau .18[F] FDG-PET/CT is a useful molecular marker in evaluating thymoma aggressiveness

Exhibition at the Malaysian Trade Exhibition 2013, PWTC

Muhammad Hishar Hassan, Fathinul Fikri, Abdul jalil Nordin.Investigation of the influence of dose minimization management on the PET image quality.

UKRC 2013, 10th -12th June, bACCLiverpool, United Kingdom.19 /2

AJ Nordin, W. A. Wan Ahmad, A. L. Ahmad, F. F. Ahmad Saad, A. Z. F. Azman, SZuhdi; Attenuation corrected PET-CT myocardial perfusion using 82Rubidium allow quantification of coronary flow reserve with improve left ventricular function assessment – a preliminary experience.

ESR Vienna 2013. 7-11 Mac.

Fathinul Fikri .18F-FDG PET-CT as a useful tool in predicting survival in patient with esophageal cancer .,

Annual Scientific meeting College of Radiology; 13 – 15 June, 2013.

Fathinul Fikri AS, Abdul Jalil N. Potential of 82Rb PET-CT as an angiogenesis marker in evaluating tumour aggressiveness.

International Cancer Imaging Society Meeting and 13th Annual Teaching Course 2013 , York, United Kingdom

F Fathinul , 1AJ Nordin, R Dharmendran, P Vikneswaran . The value of pretreatment PET-CT in predicting survival in patient with esophageal cancer.

7th National Conference for Clinical research 2013. Seri Pacific Hotel, Kuala Lumpur


PROCEEDING/POSTER 2013/14

Fathinul Fikri AS, Abdul Jalil N. Potential of 82Rb PET-CT as an angiogenesis marker in evaluating tumour aggressiveness.

Annual Scientific meeting College of Radiology; 2014

Fathinul Fikri A S, Abdul Jalil Nordin, Chemotherapy Response Evaluation in Metastatic Non-Small Lung Carcinoma (NSCLC) with 18F- FDG PET/CT and CT Scan..

Cancer Imaging.Heidelbergh. Germany 2014

S.Shahrin, F. Fathinul, S.T Subhaa, M Azriff, A.R Noraini, AF Azman , A.J. Nordin. Clinical applications of 18[F]FDG-PET/CT in nasopharyngeal carcinoma patients .

7th National Conference for Clinical research 2013. Seri Pacific Hotel, Kuala Lumpur

A. J. Nordin, S. Shahruddin, F. F. Ahmad Saad, N. Abdul Rahim, H. Hassan, S. Mustafa.Vascular Plagues Assessment using 18F-Fluorodeoxyglucose (FDG) Positron EmissionTomography (PET) and Computed Tomography (CT) during contemporaneous imaging acquisition: a preliminary study .

ECR 2014. 10.1594/ecr2014/C-2036

Mohd Hafizi Mahmud, Abdul Jalil Nordin, Fathinul Fikri Ahmad Saad, Ahmad Zaid Fattah Azman. Estimation of patient radiation dose from whole body 18F-FDG PET/CT examination in cancer imaging: a preliminary study

9th National Seminar on Medical Physics, Marriott Putrajaya, 5 April 2014

Mahmud MH, Nordin AJ, Hassan MH. Influence of body mass index on mediastinal and liver FDG uptake in whole body PET/CT imaging: a preliminary study. 2013

Annual Scientific Meeting, College of Radiology Malaysia, Kuala Lumpur, 13-15 June 2013

Ahmad Saad FF, Nordin AJ, Dharmendran R, Vikneswaran P, Mahmud MH, Hassan MH. 18F-FDG PET/CT as a useful tool in predicting survival in patient with esophageal cancer.

2013 Annual Scientific Meeting, College of Radiology Malaysia, Kuala Lumpur, 13-15 June 2013


PUBLISHED MANUSCRIPTS

Embargo Cited



Pubmed/SCOPUS Cited, IF 1.5



Chapter in Book



SCOPUS Cited



ISI Journal




SCOPUS Cited



ISI Journal

Acknowledgement

H&A Medical Supply Sdn Bhd (760352-T)

PUSAT KESIHATAN UNIVERSITIUNIVERSITI PUTRA MALAYSIA

Pusat Pengimejan Diagnostik NuklearUniversiti Putra Malaysia43400 SerdangSelangor Darul Ehsan

603-8947 1644 603-8947 2775 www.ppdn.upm.edu.my

RESEARCH ACTIVITIES & OUTPUTS

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