TEMPLATE DESIGN © 2008
www.PosterPresentations.com
THE BETHESDA SYSTEM & EVALUATION OF A PAP SMEAR IN GLANDULAR CARCINOMA
Lailatul Jalilah, M. R. , Adibah, A. R. , Mohd Hairi, A. , Siti Mariam, M. , Siti Najihah, M., Norhalifah Hanim, K., Siti Amalina, M. R. BACHELOR OF MEDICAL LAB TECHNOLOGY (HONS) , FACULTY OF HEALTH SCIENCE , UNIVERSITI TEKNOLOGI MARA , PUNCAK ALAM CAMPUS , 42300 BANDAR PUNCAK ALAM, SELANGOR.
IINTRODUCTION
ALGORITHM
ENDOMETRIAL ADENOCARCINOMA
EXTRAUTERINE ADENOCARCINOMA
CONCLUSION
ENDOCERVICAL ADENOCARCINOMA
Figure 4 : nuclear enlargement, size of nuclei is variable, prominent macronucleoli , irregular chromatin distribution , nuclear membrane
irregularities, scanty cytoplasm.
Adenocarcinoma is a cervical cancer that originates in the mucus-producing cells of the inner or endocervix, near the body of the uterus. Cervical adenocarcinoma is most common in women over 457.9% all cancer cases admitted to government hospitals are derived from cervical cancer.
• Common method of collection: PAP Smear
• Types of Glandular adenocarcinoma: Endocervical adenocarcinoma Endometrial adenocarcinoma Extrauterine adenocarcinoma
Figure 3 : nuclear enlargement , pleomorphic nuclei seen, irregular chromatin distribution and necrotic background of smear
Figure 6 : Nuclear abnormalities, including nuclear enlargement or nucleoli, moderate hyperchromasia, loss of polarity and a watery
diathesis are clues to the diagnosis
Figure 7 : Showing a cluster of adenocarcinoma with glandular pattern with cells displaying high N: C ratio, vesicular nuclei,
prominent nucleoli and scanty to moderate cytoplasm.
Figure 5 : cells in cluster , prominent macronucleoli seen, large overlapping of nuclei and tumor diathesis may be less prominent.
(R M, 2000) and (Solomon & Nayar ,2004)
(Kondo, Hashi, Murata, & Nakazawa, ,2005) and (Solomon & Nayar ,2004)
(R M ,2000) and ( Leopold G. Koss ,2006)
(P. Murugan ,2009) and (Leopold G. Koss, 2006)
Figure 8 : Cluster of cells with enlarged, variably-sized round or
oval nuclei with prominent or macronucleoli. Smear background is clean.
Figure 9 : Cells in papillary configurations and
Psammaomatus calcifications ( psammoma bodies )
REFERENCES
ASPECT ECAC EMAC EUAC
Cell Single & columnar Cluster & cuboidal Cluster & papillary
Diathesis Necrotic watery Clean
cell arrangement 2D 3D 3D
Nucleus Enlarged , variable in size
Round-oval
Enlarged , variable in size
Round-oval
Enlarged , variable in size
Round-oval
Cytoplasm Abundant cytoplasm and
finely vacuolated
Scant or abundant vacuolated cytoplasm
Scanty cytoplasm
Nucleoli Prominent nucleoli Small to prominent nucleoli
Prominentnucleoli
Others Irregular chromatin distributed
Loss of polarityIntracytoplasmic neutrophils seen
Psammoma bodies seen
(Solomon & Nayar,2004)
(Solomon & Nayar ,2004)
(Solomon & Nayar, 2004) and ( Leopold G. Koss ,2006)
Journal :• Kondo, T., Hashi, A., Murata, S.-i., & Nakazawa, T. (2005). Endocervical adenocarcinomas associated with lobular endocervical glandular hyperplasia: a report of four cases with histochemical and immunohistochemical analyses. Modern Pathology , 1199–1210.• P.Murugan, N. S. (2009). Malignant Mixed Müllerian Tumor in Ascitic Fluid: A Case Report with a Brief Review of Literature. The internet Journal of Pathology .• RM, D. (2000). Hyperchromatic crowded group : Pitfalls in pap smear Diagnosis . American Journal Clinical Pathology , 36-43.• Eduardo Lazcano-Ponce, M. D.-M.-A. (2003). Recommendations for cervical cancer screening programs in developing countries. The need for equity and technological development. salud pública de méxico , 449-462.• Edward B. Stelow, M. (2005). Endometrial Cells and the Papanicolaou Test. American Society for Clinical Pathology , 829-831.
Books :• Leopold G. Koss, M. R. (2006). Koss' diagnostic cytology and its histopathologic bases. Lippincott Williams & Wilkins.• Solomon, D., & Nayar, R. (2004). The Bethesda System For Reporting Cervical Cytology. Springer, 141-153.
Articles :• Monk, D. B. (2009, December 2). Pathogenesis of Cervical Adenocarcinoma. Women's Health and Education Center (WHEC) .• Ministry of Health, 2002. National Cancer Registry Report
Website :•Ujian Saringan untuk Kanser Sistem Pembiakan - Kanser Servik. (2008, April 28). Retrieved september 3, 2010, from My Health For life: http://portal.imateradigital.com/myhealth/bm/dewasa_content.jsp?lang=dewasa&storymaster=0&storyid=1154958496810&substoryid=1130730545609#
Table 1 : Comparison between types of adenocarcinoma
*ECAC= Endocervical Adenocarcinoma EMAC= Endometrial Adenocarcinoma EUAC= Extrauterine Adenocarcinoma
Figure 8 :The women with adenocarcinoma must immediately be referred to
a GynecologicalOncology Clinic.
(Eduardo Lazcano-Ponce, 2003)
NORMAL GLANDULAR CELLS
Figure 2 : Endometrial cells, 3D aggregates of crowded cells
scanty cytoplasm and nuclear hyperchromatin
Figure 1 : Endocervical cells, Honeycomb structure , contain of nuclei , and distinct cytoplasmic
border
(Solomon & Nayar,2004) and (Edward B. Stelow, 2005)
(R M, 2000) and (Solomon & Nayar ,2004)