Teriparatide
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Reactions 1424 - 20 Oct 2012 Teriparatide Subcutaneous nodules: case report A woman [age at onset not clearly stated] developed subcutaneous nodules during treatment with teriparatide for postparathyroidectomy hypoparathyroidism. The woman, who had undergone a thyroidectomy in 2005, presented with severe hypoparathyroidism when she was 53 years of age. Treatment with calcium and magnesium or calcitriol were not effective. Subcutaneous teriparatide injections plus calcitriol, magnesium, and calcium was partially effective but the effect did not last long. She was, therefore, treated with a multipulse SC pump-driven infusion of teriparatide, using an insulin pump device. This resulted in complete normalisation of serum calcium, magnesium, phosphate, calciuria, and magnesuria during the first day of treatment. The infusion rate was tapered down until it reached the minimal effective dose (25-35µg/day) of teriparatide. Effectiveness was maintained for 5 years. During this time, she developed subcutaneous nodules in the abdominal wall. These mostly occurred during the first year of treatment. The woman’s nodules resolved by altering the injection site and leaving the nodule region at rest. Author comment: "The only significant side effect observed during these years was the development of subcutaneous nodules". Diaz-Soto G, et al. Efficacy and safety of long term treatment of unresponsive hypoparathyroidism using multipulse subcutaneous infusion of teriparatide. Hormone and Metabolic Research 44: 708-710, No. 9, Sep 2012. Available from: URL: http://dx.doi.org/10.1055/s-0032-1308971 - Spain 803078686 1 Reactions 20 Oct 2012 No. 1424 0114-9954/10/1424-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Teriparatide
Reactions 1424 - 20 Oct 2012
Teriparatide
Subcutaneous nodules: case reportA woman [age at onset not clearly stated] developed
subcutaneous nodules during treatment with teriparatidefor postparathyroidectomy hypoparathyroidism.
The woman, who had undergone a thyroidectomy in2005, presented with severe hypoparathyroidism when shewas 53 years of age. Treatment with calcium andmagnesium or calcitriol were not effective. Subcutaneousteriparatide injections plus calcitriol, magnesium, andcalcium was partially effective but the effect did not lastlong. She was, therefore, treated with a multipulse SCpump-driven infusion of teriparatide, using an insulin pumpdevice. This resulted in complete normalisation of serumcalcium, magnesium, phosphate, calciuria, and magnesuriaduring the first day of treatment. The infusion rate wastapered down until it reached the minimal effective dose(25-35µg/day) of teriparatide. Effectiveness was maintainedfor 5 years. During this time, she developed subcutaneousnodules in the abdominal wall. These mostly occurredduring the first year of treatment.
The woman’s nodules resolved by altering the injectionsite and leaving the nodule region at rest.
Author comment: "The only significant side effectobserved during these years was the development ofsubcutaneous nodules".Diaz-Soto G, et al. Efficacy and safety of long term treatment of unresponsivehypoparathyroidism using multipulse subcutaneous infusion of teriparatide.Hormone and Metabolic Research 44: 708-710, No. 9, Sep 2012. Available from:URL: http://dx.doi.org/10.1055/s-0032-1308971 - Spain 803078686
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Reactions 20 Oct 2012 No. 14240114-9954/10/1424-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
