Reactions 1455 - 8 Jun 2013

★ STeriparatide

Myopathy (first report) in an elderly patient: casereport

An 80-year-old woman who received teriparatide developedmyopathy. She was hospitalised with a 1-year history ofmuscle cramps and lower limb weakness. She had beenasymptomatic before starting teriparatide therapy [route,dosage, indication and duration of treatment to reaction onsetnot stated]. Neurological examination revealed mild weaknessof her gluteal muscles. Electromyographic (EMG) examinationrevealed only early recruitment in her gluteus maximus andmedius muscles. Muscle MRI revealed focal areas of fattyreplacement in her gluteus muscles. Teriparatide waswithdrawn. After 3 months, her symptoms had resolved. Herclinical examination and EMG results were normal at follow-up.

Author comment: "In our case, the evidence of minimalmyopathic features on EMG examination, the presence offatty replacement documented by muscle MRI, the temporallink between teriparatide starting and symptom onset, andsymptom resolution after drug discontinuation support thehypothesis that this is a drug-induced myopathy."Luigetti M, et al. Muscle cramps and weakness after teriparatide therapy: a newdrug-induced myopathy? Muscle and Nerve 47: 615, No. 4, Apr 2013. Availablefrom: URL: http://dx.doi.org/10.1002/mus.23661 - Italy 803087867

» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports of myopathyassociated with teriparatide. The WHO ADR database contained7 reports of myopathy associated with teriparatide.

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Reactions 8 Jun 2013 No. 14550114-9954/10/1455-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved