Teriparatide
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Reactions 1455 - 8 Jun 2013 ★ S Teriparatide Myopathy (first report) in an elderly patient: case report An 80-year-old woman who received teriparatide developed myopathy. She was hospitalised with a 1-year history of muscle cramps and lower limb weakness. She had been asymptomatic before starting teriparatide therapy [route, dosage, indication and duration of treatment to reaction onset not stated]. Neurological examination revealed mild weakness of her gluteal muscles. Electromyographic (EMG) examination revealed only early recruitment in her gluteus maximus and medius muscles. Muscle MRI revealed focal areas of fatty replacement in her gluteus muscles. Teriparatide was withdrawn. After 3 months, her symptoms had resolved. Her clinical examination and EMG results were normal at follow- up. Author comment: "In our case, the evidence of minimal myopathic features on EMG examination, the presence of fatty replacement documented by muscle MRI, the temporal link between teriparatide starting and symptom onset, and symptom resolution after drug discontinuation support the hypothesis that this is a drug-induced myopathy." Luigetti M, et al. Muscle cramps and weakness after teriparatide therapy: a new drug-induced myopathy? Muscle and Nerve 47: 615, No. 4, Apr 2013. Available from: URL: http://dx.doi.org/10.1002/mus.23661 - Italy 803087867 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of myopathy associated with teriparatide. The WHO ADR database contained 7 reports of myopathy associated with teriparatide. 1 Reactions 8 Jun 2013 No. 1455 0114-9954/10/1455-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Teriparatide
Reactions 1455 - 8 Jun 2013
★ STeriparatide
Myopathy (first report) in an elderly patient: casereport
An 80-year-old woman who received teriparatide developedmyopathy. She was hospitalised with a 1-year history ofmuscle cramps and lower limb weakness. She had beenasymptomatic before starting teriparatide therapy [route,dosage, indication and duration of treatment to reaction onsetnot stated]. Neurological examination revealed mild weaknessof her gluteal muscles. Electromyographic (EMG) examinationrevealed only early recruitment in her gluteus maximus andmedius muscles. Muscle MRI revealed focal areas of fattyreplacement in her gluteus muscles. Teriparatide waswithdrawn. After 3 months, her symptoms had resolved. Herclinical examination and EMG results were normal at follow-up.
Author comment: "In our case, the evidence of minimalmyopathic features on EMG examination, the presence offatty replacement documented by muscle MRI, the temporallink between teriparatide starting and symptom onset, andsymptom resolution after drug discontinuation support thehypothesis that this is a drug-induced myopathy."Luigetti M, et al. Muscle cramps and weakness after teriparatide therapy: a newdrug-induced myopathy? Muscle and Nerve 47: 615, No. 4, Apr 2013. Availablefrom: URL: http://dx.doi.org/10.1002/mus.23661 - Italy 803087867
» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports of myopathyassociated with teriparatide. The WHO ADR database contained7 reports of myopathy associated with teriparatide.
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Reactions 8 Jun 2013 No. 14550114-9954/10/1455-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
