Aceclofenac/desmopressin
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Reactions 1461, p5 - 20 Jul 2013 S Aceclofenac/desmopressin Acute severe hyponatraemia: case report A 46-year-old man developed acute, severe hyponatraemia while receiving desmopressin and aceclofenac. The man was admitted to hospital with obtundation, lethargy and loss of consciousness. He had central diabetes insipidus and had been receiving intranasal desmopressin 10µg per day in two divided doses for 18 years. He denied any alteration to this dosage. Dizziness, headache, nausea and vomiting had developed 3 days before admission. A physical examination was normal. Laboratory tests showed a sodium level of 113 mEq/L. Further questioning revealed that he had also been receiving aceclofenac 200mg per day for 1 week [route not stated] due to lumbar pain related to weight-lifting. The man’s desmopressin was withdrawn, and he was administered hypertonic saline infusion. Within 24 hours his symptoms had resolved and his serum sodium level had increased to 123 mEq/L. On the second day after admission, his serum sodium level had normalised. The man’s desmopressin was recommenced at the usual dosage on the third day, and his continued to have a normal blood sodium level. At 1 month’s follow-up, his blood sodium level was 141 mEq/L. Author comment: "[W]e describe the case of a 46-year-old man with central diabetes insipidus undergoing long-term treatment with a constant dose of desmopressin who developed acute severe symptomatic hyponatremia when desmopressin was combined with [aceclofenac]". Bergoglio MT, et al. Acute severe hyponatremia induced by aceclofen in a male patient with central diabetes insipidus. Endocrinologia y Nutricion 60: 338-340, No. 6, Jun 2013. Available from: URL: http://dx.doi.org/10.1016/ j.endonu.2012.06.012 - Spain 803090269 1 Reactions 20 Jul 2013 No. 1461 0114-9954/13/1461-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Transcript of Aceclofenac/desmopressin
Reactions 1461, p5 - 20 Jul 2013
SAceclofenac/desmopressin
Acute severe hyponatraemia: case reportA 46-year-old man developed acute, severe hyponatraemia
while receiving desmopressin and aceclofenac.The man was admitted to hospital with obtundation,
lethargy and loss of consciousness. He had central diabetesinsipidus and had been receiving intranasal desmopressin10µg per day in two divided doses for 18 years. He denied anyalteration to this dosage. Dizziness, headache, nausea andvomiting had developed 3 days before admission. A physicalexamination was normal. Laboratory tests showed a sodiumlevel of 113 mEq/L. Further questioning revealed that he hadalso been receiving aceclofenac 200mg per day for 1 week[route not stated] due to lumbar pain related to weight-lifting.
The man’s desmopressin was withdrawn, and he wasadministered hypertonic saline infusion. Within 24 hours hissymptoms had resolved and his serum sodium level hadincreased to 123 mEq/L. On the second day after admission,his serum sodium level had normalised.
The man’s desmopressin was recommenced at the usualdosage on the third day, and his continued to have a normalblood sodium level. At 1 month’s follow-up, his blood sodiumlevel was 141 mEq/L.
Author comment: "[W]e describe the case of a 46-year-oldman with central diabetes insipidus undergoing long-termtreatment with a constant dose of desmopressin whodeveloped acute severe symptomatic hyponatremia whendesmopressin was combined with [aceclofenac]".Bergoglio MT, et al. Acute severe hyponatremia induced by aceclofen in a malepatient with central diabetes insipidus. Endocrinologia y Nutricion 60: 338-340,No. 6, Jun 2013. Available from: URL: http://dx.doi.org/10.1016/j.endonu.2012.06.012 - Spain 803090269
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Reactions 20 Jul 2013 No. 14610114-9954/13/1461-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
