ASPEK KLINIS HIPERPIGMENTASI KULIT DANPENGGUNAAN PEMUTIH KULITSintesa MelaninPATOGENESIS KELAINAN HIPERPIGMENTASIKELAINAN HIPERPIGMENTASI KULITKELAINAN HIPERMELANOSISEPIDERMALMELASMA Hipermelanosis > Preile!si " #a$a%& le'%er an len(an )er#arna *o!lat %in((a a+,'a+, A!,isita SimetrisHormonal "MSH&A-TH&LipoproteinEstro(en&Pro(esteronSinar U.Geneti!a/otosensiti0er "Kosmeti!a& o+at'o+atanIn1e!si !ronisStress Psi!isEtiolo(i Memi*,Melano(enesisGm+ran !linisMelasmaSentro1asial Pipi&a%i&atas +i+ir&%i,n(a(,MalarPipi 2 Hi,n(Mani+,larRam,s mani+,laPEMERIKSAAN PENUN3ANG Lamp, 4oo " Tipe Epiermal )er#arna *o!lat m,a Tipe Dermal )er#arna a+,'a+, Tipe -amp,ran )er#arna *o!lat (elapPENANGANANTA)IRSUR5APEMUTIH KULITPENGELUPASANKIMIA4IE/ELID 6 /RE-KLES Hipermelanosis epiermal Ma!,la !e*o!la'tan p aera%terpapar sinar U. Ke*il& atariameter 78&9*m > >> K,lit p,ti%HIPERPIGMENTASI POST IN/LAMASI:HPI; Hipermelanosis epi'ermal Ma!,la %iperpi(men Pen,n$an( " 4oo Lamp Kealaman %iperpi(mentasi Histopatolo(i "' pigment incontinence' penin(!atan melanin paa lapisan epi' ermal HPIKELAINAN HIPERMELANOSITOSIS EPIDERMALLENTIGINES Hipermelanositosis epi'ermal Ke*il& iameter 79mm Ma!,la !e*o!latan %in('(a *o!lat !e%itaman )er+atas te(as& paaaera% terpapar sinarU.& $,(a paa telapa!tan(an an telapa! !a!iKELAINAN MELANOSITOSIS DERMALNE.US OTA Hipermelanositosisermal >> Kon(enital B N> /,s*o*aer,le,sopt%almoma?illaris Ma!,la %iperpi(mentasi+ir, !e%itamana6 *o!lat a+,'a+, Distri+,si " N>Tri(eminal-a+> I 2 IINE.US OTA Dapat men(enai m,!osa !on$,n(tiAa&s*leramem+ran timpani >> !,lit Asian > Histopatolo(i Penin(!atan melanosit p er'mal>)LUE NE.US Hipermelanositosisermal Sinonim " )l,e ne,roneA,s 3aasson'Tie*%e NeA,s Dermal melanositoma Melano1i+roma )eni(na Mesen!imalMelanoma

-ommon +l,e neA,s)LUE NE.US E6 +el,m i!eta%,i +erasal ari a!,m,lasi 2i11erensiasi sel melanosit paa ermis )e+erapa +l,e neAi -DCD stem *ell-ommon +l,e neA,s " Acquired :,m,mn=a paa ana!'ana! 7 Et%n ata,masa p,+ertas;)iasan=a soliter& asimptomati!& +ir, a+,'a+, ata,pap,l +ir, !e%itaman& iameter 7 E8 mm -ommon +l,e neA,s preile!si isel,r,% t+%>> ors,m man,s an ors,m peis )LUE NE.US Cellular blue nevus )ir, !ea+,an No,l +ir, !e*o!latan Pla!& iameter E'C *m Perm,!aan %al,s& irre(,lerE6C !as,s paa +o!on( an sa*r,m Mali(nan +l,e neA,s " Per!em+an(an *ell,lar +l,e neA,s )iasan=a !om+inasi en(an NeA,s ota No,l paa ermal en(an ata, tanpa ,l!,sPEMERIKSAAN PENUN3ANG Dermos!opi " OAal Uni1orm )ir, a+,'a+, Histopatolo(i " -ommon +l,e neA,s " Penin(!atan melaninpaa ermal Histopatolo(i -ell,lar)l,e neAi " Penin(!atan melaninermal Sel'sel +erinti oAoi Dapat item,!an sel epiteloi Histopatolo(i Mali('nan +l,e neA,s " .arian melanomaPENANGANAN KELAINAN HIPERPIGMENTASIPENGELUPASANKIMIA4I)EDAH )EKUTA)IR SUR5ALASER ND'5AG& F'S#it*%eIPLPEMUTIH KULITNONMELANOSIT6NONMELANOSITOSISEXOGENOUS OCHONOS!S Hiperpi(mentasi nonmelanosit ata, nonmelanositosis Asimptomati! Preile!si " 4a$a% P,n((,n( E?tensor E!stremitas >> Tipe !,lit I. ETIOLOGIEGOGENOUS O-HRONOSISHIDROFUINON RESORSINOL PHENOL MERKURIASAM>PI-RI-ANTIMALARIA Histopatolo(i e?o(eno,s o*%ronosis " K,mp,lan (lo+,l,s o*%ronoti* :!,nin( *o!lat;paa papilla ermisTerimakasihTerimakasih