Atazanavir
1
Reactions 1341 - 5 Mar 2011 Atazanavir Lithiasis: 2 case reports Two patients developed lithiasis during treatment with atazanavir for HIV. A 51-year old man had previously experienced side effects while taking antiretrovirals, including megaloblastic anaemia, back pain and dyslipidaemia. His treatment regimen was eventually changed to ritonavir-boosted atazanavir [dosage and route not stated] combined with lamivudine and tenofovir in April 2005. In January 2008, he was hospitalised for vertigo, sweating and nausea triggered by postural changes and of a few seconds duration. Performance of the Dix and Hallpike manoeuvre resulted in paroxysmal geotropic rotatory nystagmus of short latency and period, consistent with lithiasis of the left posterior semicircular canal. The Epley manoeuvre resulted in liberating nystagmus, and was repeated, leading to disappearance of his nystagmus and improvement of his clinical condition. A 68-year-old woman had been HIV-positive since March 2000 and started antiretroviral therapy. Treatments were subsequently switched for simplification of the therapeutic regimen or due to side effects such as back pain and an altered lipid profile. In May 2009, her treatment regimen was changed to atazanavir 400 mg/day [route not stated]. About 5 weeks later, she reported swelling of the left parotid region and pain after introducing food. Ultrasonography of her parotid gland revealed stones in the principal duct [patient outcome not stated]. Author comment: "Our cases suggest that atazanavir- related lithiasis could appear in different districts other than the kidneys and urinary tract, and confirm that the onset of this side effect seems to be not related to the length of treatment." Pastori D, et al. Lithiasis of semicircular canals and parotid glands: unusual stones deposition in atazanavir-treated individuals. AIDS 23: 2233-4, No. 16, 23 Oct 2009 - Italy 803049917 1 Reactions 5 Mar 2011 No. 1341 0114-9954/10/1341-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Atazanavir
Reactions 1341 - 5 Mar 2011
Atazanavir
Lithiasis: 2 case reportsTwo patients developed lithiasis during treatment with
atazanavir for HIV.A 51-year old man had previously experienced side
effects while taking antiretrovirals, including megaloblasticanaemia, back pain and dyslipidaemia. His treatmentregimen was eventually changed to ritonavir-boostedatazanavir [dosage and route not stated] combined withlamivudine and tenofovir in April 2005. In January 2008, hewas hospitalised for vertigo, sweating and nausea triggeredby postural changes and of a few seconds duration.Performance of the Dix and Hallpike manoeuvre resulted inparoxysmal geotropic rotatory nystagmus of short latencyand period, consistent with lithiasis of the left posteriorsemicircular canal. The Epley manoeuvre resulted inliberating nystagmus, and was repeated, leading todisappearance of his nystagmus and improvement of hisclinical condition.
A 68-year-old woman had been HIV-positive sinceMarch 2000 and started antiretroviral therapy. Treatmentswere subsequently switched for simplification of thetherapeutic regimen or due to side effects such as back painand an altered lipid profile. In May 2009, her treatmentregimen was changed to atazanavir 400 mg/day [route notstated]. About 5 weeks later, she reported swelling of theleft parotid region and pain after introducing food.Ultrasonography of her parotid gland revealed stones in theprincipal duct [patient outcome not stated].
Author comment: "Our cases suggest that atazanavir-related lithiasis could appear in different districts other thanthe kidneys and urinary tract, and confirm that the onset ofthis side effect seems to be not related to the length oftreatment."Pastori D, et al. Lithiasis of semicircular canals and parotid glands: unusual stonesdeposition in atazanavir-treated individuals. AIDS 23: 2233-4, No. 16, 23 Oct 2009- Italy 803049917
1
Reactions 5 Mar 2011 No. 13410114-9954/10/1341-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
