CRP Rujukan

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Turk J Pediatr.2011 Mar-Apr;53(2):180-6.

Procalcitonin versus CRP as an early indicator of fetal

infection in preterm premature rupture of membranes.

Canpolat FE,Yiit S,Korkmaz A,Yurdakk M,Tekinalp G.

Source

Neonatology Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara,

Turkey.

Abstract

The aim of this study was to examine the diagnostic sensitivity and specificity of C-reactive

protein (CRP) and procalcitonin (PCT) in neonates who were born after preterm premature

rupture of membranes (PPROM) and compare these with interleukin-6 (IL-6). The studyinvolved 74 preterm neonates who were born after PPROM. IL-6, CRP, complete blood count

and leukocyte ratios, and PCT levels were measured in the 1st day of life, and CRP, PCT, and

blood counts were repeated on the 3rd day of life. Seventy-four infants with PPROM weredivided into two groups according to the development of sepsis and infection (Group 1: sepsis, n

= 32; Group 2: no sepsis, n = 42). There were no significant differences between these groups

with respect to gestational age, birthweight and duration of membrane rupture. There weresignificant differences between the two groups in the 1st day CRP (Group 1: 0.85 -/+ 1.36 mg/dl,

Group 2: 0.23 +/- 0.25 mg/dl; p = 0.016), 1st day PCT (Group 1: 7.2 +/- 7.6 ng/ml, Group 2, 1.6

+/- 4.0 ng/ml; p < 0.001), and 3rd day PCT (Group 1: 9.01 +/-11.5 ng/ml, Group 2: 1.34 +/- 1.35

ng/ml; p = 0.001) and IL-6 (Group 1: 80.7 +/- 67.2 pg/ml, Group 2: 3.4 +/- 3.5 ng/ml; p < 0.001)

levels. CRP levels were not significantly different between Group 1 (1.2 +/- 1.7 mg/dl) andGroup 2 (0.58 +/- 1.1 mg/dl) on the 3rd day of life (p=0.059). CRP levels on the 1st day of life

had a cut-off value of 0.72 mg/dl with a sensitivity and specificity of 56% and 58%, respectively.CRP levels on the 3rd day had a cut-off level of 0.78 mg/dl with 60% sensitivity and 63%

specificity. PCT levels had a cut-off level of 1.74 ng/ml with 76% sensitivity and 85% specificity

on the 1st day of life, and of 1.8 with 89% sensitivity and 86% specificity on the 3rd day of life.Statistical analysis revealed that the cut-off value of 7.6 pg/ml for IL-6 had a 93% sensitivity and

96.7% specificity. Interleukin (IL)-6 is the most reliable marker for the detection of early-onset

sepsis in preterm neonates with PPROM. Early PCT levels seemed to be more sensitive than

early CRP in this population.

Bangladesh Med Res Counc Bull.2011 Aug;37(2):40-6.

Role of serum procalcitonin and C-reactive protein in

the diagnosis of neonatal sepsis.

Naher BS,Mannan MA,Noor K,Shahiddullah M.
http://www.ncbi.nlm.nih.gov/pubmed/21853656http://www.ncbi.nlm.nih.gov/pubmed/21853656http://www.ncbi.nlm.nih.gov/pubmed?term=%22Canpolat%20FE%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Canpolat%20FE%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yi%C4%9Fit%20S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yi%C4%9Fit%20S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yi%C4%9Fit%20S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Korkmaz%20A%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Korkmaz%20A%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Korkmaz%20A%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yurdak%C3%B6k%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yurdak%C3%B6k%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yurdak%C3%B6k%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Tekinalp%20G%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Tekinalp%20G%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Tekinalp%20G%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/21877603http://www.ncbi.nlm.nih.gov/pubmed/21877603http://www.ncbi.nlm.nih.gov/pubmed?term=%22Naher%20BS%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Naher%20BS%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Mannan%20MA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Mannan%20MA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Mannan%20MA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Noor%20K%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Noor%20K%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Noor%20K%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Shahiddullah%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Shahiddullah%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Shahiddullah%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Shahiddullah%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Noor%20K%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Mannan%20MA%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Naher%20BS%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/21877603http://www.ncbi.nlm.nih.gov/pubmed?term=%22Tekinalp%20G%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yurdak%C3%B6k%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Korkmaz%20A%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yi%C4%9Fit%20S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Canpolat%20FE%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/21853656


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Source

Department of Neonatology, Sir Salumullah Medical College & Mitford Hospital, Dhaka.

Abstract

This cross sectional observational study was done in the division of neonatology, department ofpediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU) in the year 2007. The

study population was 50 newborns in total who needed evaluation of sepsis on clinical suspicion.

The main objective of this study was to assess serum procalcitonin (PCT) as a better diagnosticmarker than C-Reactive Protein (CRP) in neonatal sepsis. The total study populations were

classified into 4 groups like highly probable, probable, and possible and no sepsis group

according to the clinical and blood parameters. PCT and CRP were assessed and compared by

statistical analysis. For the estimation of PCT and CRP, venous blood was drawn and centrifugedand stored at - 20 degrees C in the refrigerator. Later on PCT was measured by rapid semi

quantitative immunochromatographic test. Level of CRP was determined by semi quantitative

method (latex). All data were analyzed by SPSS version 10 windows. For statistical analysisappropriate tests were done. In all observations sepsis was found to be more common in malenewborns and in those who were delivered by caesarean section. In low birth weight and preterm

newborns sepsis was more prevalent. Premature rupture of membrane (PROM) was found to be

the commonest maternal clinical condition as a risk factor of sepsis. There was positivecorrelation between serum PCT and CRP and values of serum PCT as well as CRP differed

significantly in the different categories of sepsis indicating relation to the severity of sepsis. PCT

is a useful, sensitive and independent biomarker of neonatal sepsis. CRP measurement alongwith PCT measurement may increase the specificity. Though PCT measurement is comparatively

expensive but an easy bed side promt convenient procedure for sick neonates in addition to CRP

for rapid evaluation of neonatal sepsis rather than waiting for the report of blood culture.

Placenta.2011 Oct;32(10):732-6. Epub 2011 Aug 11.

Predictive value of intra-amniotic and serum markers

for inflammatory lesions of preterm placenta.

Oh KJ,Park KH,Kim SN,Jeong EH,Lee SY,Yoon HY.

Source

Department of Obstetrics and Gynecology, Seoul National University College of Medicine,Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do 463-707, Republic of

Korea.

Abstract
http://www.ncbi.nlm.nih.gov/pubmed/21839511http://www.ncbi.nlm.nih.gov/pubmed/21839511http://www.ncbi.nlm.nih.gov/pubmed?term=%22Oh%20KJ%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Oh%20KJ%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Park%20KH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Park%20KH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Park%20KH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Kim%20SN%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Kim%20SN%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Kim%20SN%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Jeong%20EH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Jeong%20EH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Jeong%20EH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Lee%20SY%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Lee%20SY%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Lee%20SY%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yoon%20HY%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yoon%20HY%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yoon%20HY%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Yoon%20HY%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Lee%20SY%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Jeong%20EH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Kim%20SN%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Park%20KH%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Oh%20KJ%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/21839511


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OBJECTIVE:

To compare the relative predictive values of amniotic fluid (AF) matrix metalloproteinase-9(MMP-9), interleukin-6 (IL-6), and serum C-reactive protein (CRP) for histologic

chorioamnionitis and intra-amniotic infection in women with preterm labor or preterm premature

rupture of membranes (PROM).

STUDY DESIGN:

This retrospective cohort study included 99 consecutive women with preterm labor or preterm

PROM (21-35 weeks' gestation) who delivered within 72 h of transabdominal amniocentesis.The AF was cultured for aerobic and anaerobic bacteria and for genital mycoplasmas and was

assayed for MMP-9 and IL-6 levels. Maternal serum CRP was measured immediately after

amniocentesis. The placentas were examined histologically.

MAIN OUTCOME MEASURES:

histologic chorioamnionitis and intra-amniotic infection.

RESULTS:

The prevalence of histologic chorioamnionitis and a positive AF culture was 44% (44/99) and

28% (28/99), respectively. In predicting intra-amniotic infection, AF MMP-9 had a significantlyhigher area under the curve (AUC: 0.94 [95% CI, 0.87-0.98]) than AF IL-6 (0.87 [95% CI, 0.78-

0.84]; P < 0.05) and serum CRP (0.76 [95% CI, 0.66-0.84]; P < 0.001) and a higher sensitivity

and specificity than serum CRP (P < 0.01, respectively). However, in predicting histologic

chorioamnionitis, there were no significant differences in AUCs among the three tests (AF

MMP-9: 0.78 [95% CI, 0.68-0.85]; AF IL-6: 0.76 [95% CI, 0.66-0.84]; serum CRP: 0.76 [95%CI, 0.66-0.84]). In a sub-analysis of 71 women without intra-amniotic infection, histologic

chorioamnionitis was associated with an elevated serum CRP level (P < 0.05), but not with thelevel of AF IL-6 or MMP-9 (P = 0.232 and P = 0.402, respectively).

CONCLUSIONS:

The AF MMP-9 has a better overall diagnostic performance than the AF IL-6 and maternalserum CRP in predicting intra-amniotic infection. However, the serum CRP level obtained up to

72 h before delivery appears to be an important marker for early identification of histologic

chorioamnionitis in women without intra-amniotic infection.

Copyright 2011 Elsevier Ltd. All rights reserved.

BMC Pregnancy Childbirth.2011 Apr 7;11:26.
http://www.ncbi.nlm.nih.gov/pubmed/21470433http://www.ncbi.nlm.nih.gov/pubmed/21470433http://www.ncbi.nlm.nih.gov/pubmed/21470433


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Maternal markers for detecting early-onset neonatal

infection and chorioamnionitis in cases of premature rupture

of membranes at or after 34 weeks of gestation: a two-center

prospective study.Popowski T,Goffinet F,Maillard F,Schmitz T,Leroy S,Kayem G.

Source

Epidemiological Research Unit on Perinatal and Women's Health, INSERM U953, Paris, France.

[email protected]

Abstract

BACKGROUND:

Accurate prediction of infection, including maternal chorioamnionitis and early-onset neonatal

infection, remains a critical challenge in cases of preterm rupture of membranes and mayinfluence obstetrical management. The aim of our study was to investigate the predictive value

for early-onset neonatal infection and maternal histological and clinical chorioamnionitis of

maternal biological markers in routine use at or after 34 weeks of gestation in women with

premature rupture of membranes.

METHODS:

We conducted a two-center prospective study of all women admitted for premature rupture ofmembranes at or after 34 weeks of gestation. The association of C-reactive protein, white bloodcell count, vaginal sample bacteriological results, and a prediction model at admission, for early-

onset neonatal infection and maternal chorioamnionitis were analyzed by comparing areas under

the receiver operating characteristic curves and specificity.

RESULTS:

The study included 399 women. In all, 4.3% of the newborns had an early-onset neonatal

infection and 5.3% of the women had clinical chorioamnionitis. Histological chorioamnionitis

was detected on 10.8% of 297 placentas tested. White blood cell counts and C-reactive protein

concentrations were significantly associated with early-onset neonatal infection and included in aprediction model. The area under the receiver operating characteristic curve of this model was

0.82 (95% CI [0.72, 0.92]) and of C-reactive protein, 0.80 (95% CI [0.68, 0.92]) (p = 1.0).

Specificity was significantly higher for C-reactive protein than for the prediction model (48%and 43% respectively, p < 0.05). C-reactive protein was associated with clinical and histological

chorioamnionitis, with areas under the receiver operating characteristic curve of 0.61 (95% CI

[0.48, 0.74]) and 0.62 (95% CI [0.47, 0.74]), respectively.
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Popowski%20T%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Popowski%20T%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Goffinet%20F%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Goffinet%20F%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Goffinet%20F%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Maillard%20F%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Maillard%20F%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Maillard%20F%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Schmitz%20T%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Schmitz%20T%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Schmitz%20T%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Leroy%20S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Leroy%20S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Leroy%20S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Kayem%20G%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Kayem%20G%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Kayem%20G%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Kayem%20G%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Leroy%20S%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Schmitz%20T%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Maillard%20F%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Goffinet%20F%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Popowski%20T%22%5BAuthor%5D


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CONCLUSIONS:

The concentration of C-reactive protein at admission for premature rupture of membranes is themost accurate infectious marker for prediction of early-onset neonatal infection in routine use

with a sensitivity > 90%. A useful next step would be a randomized prospective study of

management strategy comparing CRP at admission with active management to assess whetherthis more individualized care is a safe alternative strategy in women with premature rupture of

membranes at or after 34 weeks.

Bratisl Lek Listy.2009;110(10):623-6.

Procalcitonin, neopterin and C-reactive protein in

diagnostics of intrauterine infection and preterm delivery.

Greksova K,Parrak V,Chovancova D,Stencl P,Oravec J,Marsik L,Sysak R,Fuchs D,Peskova Z,Borovsky

M.

Source

1st Department of Gynaecology and Obstetrics of Comenius University, Bratislava, Slovakia.

[email protected]

Abstract

OBJECTIVE:

The purpose of this study was to find out whether Procalcitoni, Neopterin and C-reactive protein

are sensitive and specific markers of intrauterine infection.

METHODS:

We evaluated 155 patients from 26. to 41. week of pregnancy at the time of delivery. We

measured serum concentrations of procalcitonin (PCT), neopterin and C-reactive protein (CRP)

from mother's blood sample at the beginning of delivery and from umbilical cord blood after

delivery.

RESULTS:

In first group occurred in higher percentage (27.41%) preterm delivery (26.-37. week of

pregnancy), chorioamnionitis confirmed by histological examination (16.12%) and pretermpremature rupture of membranes (24.19%). In this group occured perinatal infection of newborn

in 61.29%. In the second group preterm delivery (6.31%) and perinatal infection of newborn

(7.36%) occured in lower percentage.
http://www.ncbi.nlm.nih.gov/pubmed/20017453http://www.ncbi.nlm.nih.gov/pubmed/20017453http://www.ncbi.nlm.nih.gov/pubmed?term=%22Greksova%20K%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Greksova%20K%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Parrak%20V%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Parrak%20V%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Parrak%20V%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Chovancova%20D%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Chovancova%20D%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Chovancova%20D%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Stencl%20P%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Stencl%20P%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Stencl%20P%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Oravec%20J%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Oravec%20J%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Oravec%20J%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Marsik%20L%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Marsik%20L%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Marsik%20L%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Sysak%20R%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Sysak%20R%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Sysak%20R%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Fuchs%20D%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Fuchs%20D%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Fuchs%20D%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Peskova%20Z%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Peskova%20Z%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Peskova%20Z%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Borovsky%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Borovsky%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Borovsky%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Borovsky%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Borovsky%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Borovsky%20M%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Peskova%20Z%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Fuchs%20D%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Sysak%20R%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Marsik%20L%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Oravec%20J%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Stencl%20P%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Chovancova%20D%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Parrak%20V%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Greksova%20K%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/20017453


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CONCLUSION:

The results suggest that the simultaneous measurement of CRP, PCT and NPT in mother's bloodsample before delivery and umbilical cord blood may provide an accurate early diagnosis of

infection and then preterm delivery (Tab. 1, Fig. 3, Ref. 18). Full Text (Free, PDF) www.bmj.sk.

[Maternal serum cytokine levels in

pregnancies complicated by PROM].

[Article in Polish]

Poniedziaek-Czajkowska E,Leszczyska-Gorzelak B,Oleszczuk J.

Source

Kliniki Pooznictwa i Perinatologii II Katedry Pooznictwa i Chorb Kobiecych AM w Lublinie.

Abstract

OBJECTIVE:

The aim of the study was to evaluate the maternal serum cytokines levels in pregnancies

complicated by premature rupture of membranes (PROM).

MATERIALS AND METHODS:

Maternal serum of IL-1 beta, IL-4, IL-6, IL-8 and TNF-alfa levels were assessed in patients with

PROM between 24-34 weeks of pregnancy (n = 45). Control group consisted of healthy pregnant

women (n = 41) at 24-34 weeks of gestation. Serum cytokines concentrations were measured by

commercial available enzyme-linked immunosorbent assays. C-reactive protein level and WBCwere estimated in both groups.

RESULTS:

Compared to healthy pregnant, the group of patients with PROM had significantly higher serum

levels of IL-1 beta (0.76 pg/ml vs 0.41 pg/ml, p = 0.022), TNF-alfa (1332.46 pg/ml vs 58.01

pg/ml, p < 0.00001) and IL-8 (15.79 pg/ml vs 0 pg/ml, p < 0.00001). CRP concentration andWBC were also significantly higher in serum of pregnant women with PROM then in healthy

ones (CRP: 10 mg/l vs 0 mg/l, p = 0.043; WBC: 13,188 +/- 3625/mm3 vs 9132 +/- 1913/mm3, p< 0.00001). No significant differences in IL-6 and IL-4 levels were found between groups.
http://www.ncbi.nlm.nih.gov/pubmed?term=%22Poniedzia%C5%82ek-Czajkowska%20E%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Poniedzia%C5%82ek-Czajkowska%20E%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Poniedzia%C5%82ek-Czajkowska%20E%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Leszczy%C5%84ska-Gorzelak%20B%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Leszczy%C5%84ska-Gorzelak%20B%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Leszczy%C5%84ska-Gorzelak%20B%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Leszczy%C5%84ska-Gorzelak%20B%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Oleszczuk%20J%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Oleszczuk%20J%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Oleszczuk%20J%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Oleszczuk%20J%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Leszczy%C5%84ska-Gorzelak%20B%22%5BAuthor%5Dhttp://www.ncbi.nlm.nih.gov/pubmed?term=%22Poniedzia%C5%82ek-Czajkowska%20E%22%5BAuthor%5D


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