Pregabalin
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Reactions 1196 - 5 Apr 2008 S Pregabalin Generalised seizures in a patient with renal impairment: case report A 47-year-old man, who had renal impairment, which was thought to be due to long-term ketoprofen therapy, developed generalised seizures during treatment with pregabalin. The man, who had neuropathic pain secondary to type 2 diabetes mellitus, started receiving pregabalin 75 mg/day; he was also receiving ketoprofen, metformin and perindopril. After this, he developed fatigue, three episodes of falls, and difficulty concentrating [time to reaction onset not stated]. Five days after pregabalin initiation, he was hospitalised after having a generalised seizure in an emergency room. Laboratory tests revealed a serum creatinine level of 499 µmol/L and a urea level of 28.6 mmol/L. Pregabalin, ketoprofen, metformin and perindopril were held on admission. By day 4, his serum creatinine level had decreased to 148 µmol/L and his urea level had decreased to 17 mmol/L. His level of cognition returned to normal and he was discharged. Author comment: "Pregabalin is renally cleared as an unchanged drug and dosage reduction with decreased renal function is recommended. The patient’s renal dysfunction was thought to be due to his long-term ketoprofen therapy as his creatinine returned to normal after it was discontinued. . . A Naranjo ADR probability scale of 4 suggests a possible adverse drug reaction." Pang S, et al. Pregabalin-associated seizures. Canadian Journal of Hospital Pharmacy 61 (Suppl. 1): 47, Jan 2008 [abstract] - Canada 801105295 1 Reactions 5 Apr 2008 No. 1196 0114-9954/10/1196-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Pregabalin
Reactions 1196 - 5 Apr 2008
SPregabalin
Generalised seizures in a patient with renalimpairment: case report
A 47-year-old man, who had renal impairment, which wasthought to be due to long-term ketoprofen therapy, developedgeneralised seizures during treatment with pregabalin.
The man, who had neuropathic pain secondary to type 2diabetes mellitus, started receiving pregabalin 75 mg/day; hewas also receiving ketoprofen, metformin and perindopril.After this, he developed fatigue, three episodes of falls, anddifficulty concentrating [time to reaction onset not stated]. Fivedays after pregabalin initiation, he was hospitalised afterhaving a generalised seizure in an emergency room.Laboratory tests revealed a serum creatinine level of499 µmol/L and a urea level of 28.6 mmol/L.
Pregabalin, ketoprofen, metformin and perindopril wereheld on admission. By day 4, his serum creatinine level haddecreased to 148 µmol/L and his urea level had decreased to17 mmol/L. His level of cognition returned to normal and hewas discharged.
Author comment: "Pregabalin is renally cleared as anunchanged drug and dosage reduction with decreased renalfunction is recommended. The patient’s renal dysfunctionwas thought to be due to his long-term ketoprofen therapy ashis creatinine returned to normal after it was discontinued. . .A Naranjo ADR probability scale of 4 suggests a possibleadverse drug reaction."Pang S, et al. Pregabalin-associated seizures. Canadian Journal of HospitalPharmacy 61 (Suppl. 1): 47, Jan 2008 [abstract] - Canada 801105295
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Reactions 5 Apr 2008 No. 11960114-9954/10/1196-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
