Pregabalin overdose
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Reactions 1477, p27 - 9 Nov 2013 O S Pregabalin overdose Tonic-clonic seizure: case report A 54-year-old woman developed tonic-clonic seizure after administering an overdose of pregabalin. The woman presented after ingesting 51 × pregabalin 75mg tablets (3825mg). She was alert and conscious on arrival, yet obtundation rapidly ensued with response solely to deep sternal rub. She experienced a tonic-clonic seizure at around 10 hours after overdosing; right gaze deviation and involuntary mouth movements with foaming were also noted. The self- limiting seizure persisted for around 1 minute after which obtundation returned. Lorazepam was initiated with supportive therapy; the woman regained baseline mental status, a few hours later. Her pregabalin concentration was 58 µg/mL, at around 5 hours after overdosing. Author comment: "To our knowledge, this is the first case of a seizure associated with isolated pregabalin overdose. The serum level observed in this patient is among the highest reported in the literature." Gorodetsky RM, et al. Seizures in the setting of large pregabalin overdose. Clinical Toxicology 50: 322 abstr. 179, No. 4, Apr 2012. Available from: URL: http:// dx.doi.org/10.3109/15563650.2012.669957 - USA 803095509 1 Reactions 9 Nov 2013 No. 1477 0114-9954/13/1477-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Transcript of Pregabalin overdose
Reactions 1477, p27 - 9 Nov 2013
O SPregabalin overdose
Tonic-clonic seizure: case reportA 54-year-old woman developed tonic-clonic seizure after
administering an overdose of pregabalin.The woman presented after ingesting 51 × pregabalin 75mg
tablets (3825mg). She was alert and conscious on arrival, yetobtundation rapidly ensued with response solely to deepsternal rub. She experienced a tonic-clonic seizure at around10 hours after overdosing; right gaze deviation and involuntarymouth movements with foaming were also noted. The self-limiting seizure persisted for around 1 minute after whichobtundation returned.
Lorazepam was initiated with supportive therapy; thewoman regained baseline mental status, a few hours later. Herpregabalin concentration was 58 µg/mL, at around 5 hoursafter overdosing.
Author comment: "To our knowledge, this is the first caseof a seizure associated with isolated pregabalin overdose. Theserum level observed in this patient is among the highestreported in the literature."Gorodetsky RM, et al. Seizures in the setting of large pregabalin overdose. ClinicalToxicology 50: 322 abstr. 179, No. 4, Apr 2012. Available from: URL: http://dx.doi.org/10.3109/15563650.2012.669957 - USA 803095509
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Reactions 9 Nov 2013 No. 14770114-9954/13/1477-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
