Chlorambucil/melphalan
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Reactions 947 - 19 Apr 2003 ★ Chlorambucil/melphalan First report of allergic contact dermatitis following occupational exposure: case report A 21-year-old man developed allergic contact dermatitis to chlorambucil and melphalan following occupational exposure. The man developed an itchy rash on his face 1 week after starting work in a laboratory where he was exposed to chlorambucil and melphalan. His rash initially appeared over his face where his respiratory dust mask touched his skin, then spread to uncovered areas. He stopped working in the laboratory until his rash resolved. His reaction was thought to be due to latex in the nose clip of the mask and he tried using a paper dust mask but his rash recurred. He again stopped working in the laboratory and his rash cleared but it recurred when handling paperwork from the laboratory. At the time of his rash onset he had been working with melphalan, but chlorambucil was also present in the laboratory. The man underwent patch testing which yielded positive reactions to chlorambucil and melphalan and he was diagnosed as having allergic contact dermatitis from chlorambucil and melphalan. Author comment: "We thought that the primary sensitization was probably to melphalan, with cross-sensitivity to chlorambucil, as melphalan was the main drug with which the patient had been working prior to the onset of the rash." Goon AT-J, et al. Allergic contact dermatitis from melphalan and chlorambucil: cross-sensitivity or cosensitization? Contact Dermatitis 47: 309-310, Nov 2002 - England 800932529 » Editorial comment: A search of AdisBase, Medline and the WHO Adverse Drug Reactions database did not reveal any previous case reports of allergic contact dermatitis associated with chlorambucil or melphalan. 1 Reactions 19 Apr 2003 No. 947 0114-9954/10/0947-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Chlorambucil/melphalan
Reactions 947 - 19 Apr 2003
★Chlorambucil/melphalan
First report of allergic contact dermatitis followingoccupational exposure: case report
A 21-year-old man developed allergic contact dermatitis tochlorambucil and melphalan following occupational exposure.
The man developed an itchy rash on his face 1 week afterstarting work in a laboratory where he was exposed tochlorambucil and melphalan. His rash initially appeared overhis face where his respiratory dust mask touched his skin, thenspread to uncovered areas. He stopped working in thelaboratory until his rash resolved. His reaction was thought tobe due to latex in the nose clip of the mask and he tried using apaper dust mask but his rash recurred. He again stoppedworking in the laboratory and his rash cleared but it recurredwhen handling paperwork from the laboratory. At the time ofhis rash onset he had been working with melphalan, butchlorambucil was also present in the laboratory.
The man underwent patch testing which yielded positivereactions to chlorambucil and melphalan and he wasdiagnosed as having allergic contact dermatitis fromchlorambucil and melphalan.
Author comment: "We thought that the primarysensitization was probably to melphalan, with cross-sensitivityto chlorambucil, as melphalan was the main drug with whichthe patient had been working prior to the onset of the rash."Goon AT-J, et al. Allergic contact dermatitis from melphalan and chlorambucil:cross-sensitivity or cosensitization? Contact Dermatitis 47: 309-310, Nov 2002 -England 800932529
» Editorial comment: A search of AdisBase, Medline and theWHO Adverse Drug Reactions database did not reveal anyprevious case reports of allergic contact dermatitis associatedwith chlorambucil or melphalan.
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Reactions 19 Apr 2003 No. 9470114-9954/10/0947-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
