STEMI - Pembacaan Kardio2

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    Stemi Inferoposterior et RV

    Onset 3 Hours Killip I

    Presented by:

    Muh. Ayyub Primadi

    Supervisor :

    dr. Abdul Hakim Alkatiri, Sp.JP, FIHA

    Department of Cardiology and Vascular MedicineMedical Faculty of Hasanuddin University

    Makassar

    2013

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    PATIENT IDENTITY

    Medical Record : 622664

    Name : Mr. R

    Gender : Male Age : 31 years old

    Address : Maros

    Date of admission : 13 Agustus 2013

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    HISTORY TAKING Chief complaint:

    Chest Pain

    History of Present Illness:

    The chest pain began since 3 hours ago before he was admitted to Wahidin

    Sudirohusodo Hospital. The sensation of chest pain suddenly appeared when the patient

    was resting at home. The pain is described like dull heavy feeling on the left chest, radiated

    to his back, shoulder and left hand. The chest pain was accompanied with cold sweat and

    tightness sensation. The patient felt nausea and not vomiting. The chest pain felt

    continuously more than 20 minutes duration, and not relieved by rest.

    The patient felt breathlessness while having chest pain, and it was accompanied by

    palpitation and cold sweat. He never wakes up from her sleep in the night because of

    breathlessness. He could sleep with 1 pillow only. There was no cought and fever. No

    history of epigastric pain. Urination and defecation were normal.

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    HISTORY TAKING

    History of Past Illness: History of chest pain before (-)

    History of smoking ( + ) 2 packs/day

    History of hypertension : denied

    History of drinking alcohol (-)

    No history of heart disease

    No family history of heart disease

    History of diabetes mellitus : denied

    No history of dyslipidemia

    No history of asthma

    No history of epigastric pain

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    RISK FACTOR

    Gender:

    Male

    Non

    Modifiable

    Smoking (+)

    Obesitas (+)

    Modifiable

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    PHYSICAL EXAMINATION

    General Status

    Moderate illness/obes 1/conscious

    Vital Signs

    BP : 130/80 mmHg

    HR : 70 bpm, regular

    RR : 22 tpm

    T : 36.7C

    BW : 82 kg

    H :170 cm

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    PHYSICAL EXAMINATION

    Head Examination

    Eyes : Anemic -/-, Icterus -/-

    Lips : Cyanosis (-)

    Neck : Lymphadenopathy (-), JVP R+1 cmH2O

    Thorax Examination

    Insp. : Symmetrical R=L, normochest

    Palp. : Mass (-), tenderness (-), VF R=L

    Perc. : Sonor

    Ausc. : Vesicular

    Ronchi -/-,

    Wheezing -/-

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    PHYSICAL EXAMINATION

    Cardiac Examination

    Insp. : IC wasnt visible Palp. : IC wasnt palpable

    Perc. : Dull, normal heart size

    Right border : Right parasternalis line

    Left border : Left medioclavicularis line

    Ausc. : Pure regular of I/II heart sound, murmur

    (-)

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    PHYSICAL EXAMINATION

    Abdominal Examination

    Insp. : Flat and following breath movement

    Ausc. : Peristaltic sound (+), normal

    Palp. : Liver and spleen is unpalpable

    Perc. : Tympani (+), ascites (-)

    Extremities

    Oedema : Pretibial -/-, Dorsum pedis -/-

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    ELECTROCARDIOGRAPHY

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    ELECTROCARDIOGRAPHY

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    ELECTROCARDIOGRAPHY

    Interpretation:

    Rhythm : Sinus

    QRS-Rate : HR 75 bpm, reguler

    P-Wave : 0.08 sec

    PR-Interval : 0.16 sec

    QRS Complex : 0.08 sec

    Axis : 120

    ST-Segment : ST-elevation on lead II, III, aVF, V3R, V4R, V5R, V6R, V8, and V9.ST-depretion on lead V2, V3, V4, V5, and V6

    T-Wave : Normal

    Conclusion: Sinus Rhythm, HR 75 bpm, RAD, inferoposterior and right ventricular acute myocardialinfarction, whole anterior ischaemic.

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    CHEST X-RAY

    14 Agustus 2013

    Normal pulmonary

    CTI: Normal

    Result: Normal Pulmo

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    LABORATORY EXAMINATION

    WBC : 23,7 x 103/mm

    HB : 16,4 gr/dl

    PLT : 312.000

    HCT : 49,7 %

    GDS : 123 mg/dl

    Ureum : 15 mg/dl

    Creatinin : 0,8 mg/d

    PT : 21,7 (0,8)

    APTT : 52,4 (26,6)

    CK : 281 U/L

    CKMB : 22 U/L

    Trop. T : 0,02 Na : 141 mmol/l

    K : 4,2 mmol/l

    Cl : 107 mmol/l

    SGOT : 31 U/L SGPT : 34 U/L

    Albumin : 4,0 gr/dl

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    DIAGNOSIS

    - STEMI Inferioposterior + Right

    Ventricular onset 3 hours KILLIP I

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    INITIAL MANAGEMENT

    Bed rest

    O2 2-4 LPM (via nasal canule)

    IVFD NaCl 0,9% loading 500 cc/24 hours

    Anti Platelet Aggregation

    ASA (Aspilet) loading dose 160 mg (2 x 80 mg) maintenance 1-0-0

    Clopidogrel (Plavix) loading dose 300 mg (4 x 75 mg)maintenance 0-1-0

    Anti cholesterol

    HMG-Co A reductase inhibitor (Simvastatin 1 x 20 mg)

    Trombolitik

    Streptokinase (Streptase 1,5 million units were dissolved in 100 ml of

    Dextrose 5% in drips for 1 hour) Anxiolytic

    Benzodiazepin (Alprazolam 1 x 0,5 mg)

    Laxative

    Laxadin syrup 1 x 2 cth

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    ELECTROCARDIOGRAPHY

    Post Trombolitik

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    PLANNING

    Echocardiography

    Coronary angiography

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    ACUTE CORONARY SYNDROME

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    DIAGNOSIS OF CHEST PAIN

    3 point typical chest painTend to be Stable Angina Pectoris than Acute Coronary

    Syndrome

    2 point atypical chest painTend to be Acute Coronary Syndrome than Non Cardiac

    Chest Pain

    1 point or none non cardiac chest

    pain

    Retrosternalor substernalchest pain

    1point Increased by

    activity oremotion

    1point Relieved by

    resting ornitrate SL

    1point

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    DEFINITION

    Acute Coronary Syndrome (ACS) is a term for situations

    where the blood supplied to the heart muscle is

    suddenly blocked.

    describe a group of conditions resulting from

    acute myocardial ischemia (insufficient blood flow to

    heart muscle)

    ranging from unstable angina (increasing,

    unpredictable chest pain) to myocardial

    infarction (heart attack).

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    CLASSIFICATION

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    PATHOPHYSIOLOGY

    Vulnerable Plaque

    Thrombosis

    Vasospasme

    Plaque disruption andthrombosis that result incomplete coronaryartery occlusion leads totransmural ischemia and

    necrosis, the hallmark ofST-segment elevationmyocardial infarction(STEMI)

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    Lipid transport disorder Inflamation

    Plaque deposition

    Stable plaque Plaque ruptureErosion

    Stable angina pectorisThrombosis

    Thrombus

    Acute coronary syndrome:

    Unstable angina

    Myocardial infarction :

    - Non Q waves

    - Q waves

    PATHOGENESIS

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    At least 2 of the following:

    DIAGNOSIS OF ACS

    1. Ischemic symptoms

    2. Diagnostic ECG changes

    3. Serum cardiac marker elevations

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    Prolonged pain (usually >20

    minutes) constricting, crushing,

    squeezing

    Usually retrosternal location,

    radiating to left chest, left arm; can

    be epigastric

    Dyspnea

    Diaphoresis

    Palpitations

    Nausea/vomiting

    1. ISCHEMIC SYMPTOMS

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    2. DIAGNOSTIC ECG CHANGES

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    ECG CHANGESTiming of myocardial infarction based on ECG

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    3. SERUM CARDIAC MARKER

    ELEVATIONS

    Troponin T CK-MB CK

    SGOT LDH Myoglobin

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    CARDIAC BIOMARKER

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    No

    Yes

    YesNo

    STEMIAcute Myocardial Infarction

    ( Q-wave, non-Q wave )

    NSTEMI(No ST-Segment Elevation

    Myocardial Infarction)

    Unstable Angina

    Signs of myocardial ischemia

    ST segmen elevation ?

    Biochemical cardiac markers ?

    DIAGNOSIS

    ECG

    Lab

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    MYOCARDIAL INFARCTION

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    DEFINITION

    Myocardial infarction (MI) is rapid development of

    myocardial necrosis caused by imbalance oxygen

    supply and demand of the myocardium.

    It results from plaque rupture with thrombus

    formation in a coronary vessels, resulting in an acute

    reduction of blood supply to a part of the

    myocardium.

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    PATHOPHYSIOLOGY

    Vulnerable Plaque Thrombosis

    Vasospasme

    Plaque disruption and

    thrombosis that result in

    complete coronary artery

    occlusion leads to

    transmural ischemia andnecrosis, the hallmark of

    ST-segment elevation

    myocardial infarction

    (STEMI)

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    RISK FACTOR

    Gender and Age

    Men, increased risk after age 45

    Women, increased risk after age 55

    Family History

    Heart disease diagnosed before age

    55 in father or brother

    Heart disease diagnosed before age

    65 in mother or sister

    Non- Modifiable Modifiable

    Smoking

    Hypertension

    Diabetes Mellitus

    Dyslipidemia

    Obesity

    Lack of physical activity

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    WHO DIAGNOSTIC CRITERIA

    Clinical historyof ischaemictype chest pain lasting >20minutes

    Changes in serial ECG tracings

    Riseof serum cardiacbiomarkerssuch as creatininekinase-MB fraction and troponin

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    CLINICAL HISTORY

    Duration : variable, often more than 30 minutes.

    Quality : Feels squeezing, pressurelike, tightness,

    heaviness, and burning.

    Location : Retrosternal, often with radiation to orisolated discomfort in neck, jaw, shoulders, or arms

    frequently on left.

    Associated features : Not relieve with rest or nitrat

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    ECG CHANGESTiming of myocardial infarction based on ECG

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    CARDIAC BIOMARKER

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    DIAGNOSIS

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    THROMBOLYTIC AGENTINDICATIONS

    Age < 70 yo

    Typical chest pain, > 20 minutes, not

    relieved by nitrat

    ST elevation > 0,1 mV, on 2 lead or more

    Onset < 12 hours

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    THROMBOLYTIC AGENT

    Absolute: Previous intracranial

    haemorrhage or stroke ofunknown origin at any time

    Central nervous systemdamage or neoplasms

    Recent majortrauma/surgery/head injury(within the preceding 3 weeks)

    Gastrointestinal bleeding

    within the past month Known bleeding disorder

    (excluding menses)

    Aortic dissection

    Relative: Transient ischaemic attack in

    the preceding 6 months

    Oral anticoagulant therapy

    Pregnancy or within 1 weekpostpartum

    Refractory hypertension(systolic blood pressure >180mmHg and/or diastolic bloodpressure >110 mmHg)

    Advanced liver disease

    Infective endocarditis

    Prolonged or traumaticresuscitation

    CONTRAINDICATIONS

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    PROGNOSIS

    KILLIP CLASSIFICATION

    Class DescriptionMortality Rate

    (%)

    I No clinical signs of heart failure 6

    IIRales or crackles in the lungs, anS3, and elevated jugular venous

    pressure

    17

    III Acute pulmonary edema 30 - 40

    IV

    Cardiogenic shock orhypotension (systolic BP < 90

    mmHg), and evidence of

    peripheral vasoconstriction

    60 80

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    PROGNOSIS TIMI SCORE

    HistoricalAge 65-74

    >/= 75

    2 points

    3 points

    DM/HTN or Angina 1 point

    ExamSBP < 100 3 points

    HR > 100 2 points

    Killip II-IV 2 points

    Weight > 67 kg 1 point

    PresentationAnterior STE or LBBB 1 point

    Time to treatment > 4 hrs 1 point

    Risk Score = Total (0-14)

    Total

    Score Risk of Deathin 30 days0 0.8%

    1 1.6%

    2 2.2%

    3 4.4%

    4 7.3%

    5 12.4%

    6 16.1%

    7 23.4%

    8 26.8%

    9-14 35.9%

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    THANK YOU