Terlipressin
1
Reactions 1497, p37 - 19 Apr 2014 S Terlipressin Skin necrosis: case report A 54-year-old man developed skin necrosis during treatment with terlipressin for worsening renal function. The man, who had alcoholic cirrhosis, was hospitalised due to ascites and hepatorenal syndrome. Due to worsening renal function, he began receiving terlipressin 1mg every 6 hours [route not stated]. A few days later, he developed extensive purpuric lesions with haemorrhagic blisters on his buttocks, trunk and inferior limbs. A skin biopsy showed epidermal ulceration with RBC extravasation and partial occlusion of vessels. He was diagnosed with terlipressin-induced skin necrosis. Terlipressin was withdrawn and the man’s lesions stopped progressing. Due to renal failure, terlipressin was restarted and the man’s skin lesions worsened. He subsequently died due to irreversible liver failure. Author comment: "Terlipressin-induced skin necrosis is an extremely rare ischemic event." Leiva-Salinas M, et al. Extensive cutaneous necrosis induced by terlipressin. Journal of the American Academy of Dermatology 70: AB151 abstr. P8608, No. 51, 1 May 2014 - Spain 803102015 1 Reactions 19 Apr 2014 No. 1497 0114-9954/14/1497-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
Transcript of Terlipressin
Reactions 1497, p37 - 19 Apr 2014
STerlipressin
Skin necrosis: case reportA 54-year-old man developed skin necrosis during
treatment with terlipressin for worsening renal function.The man, who had alcoholic cirrhosis, was hospitalised due
to ascites and hepatorenal syndrome. Due to worsening renalfunction, he began receiving terlipressin 1mg every 6 hours[route not stated]. A few days later, he developed extensivepurpuric lesions with haemorrhagic blisters on his buttocks,trunk and inferior limbs. A skin biopsy showed epidermalulceration with RBC extravasation and partial occlusion ofvessels. He was diagnosed with terlipressin-induced skinnecrosis.
Terlipressin was withdrawn and the man’s lesions stoppedprogressing.
Due to renal failure, terlipressin was restarted and the man’sskin lesions worsened. He subsequently died due toirreversible liver failure.
Author comment: "Terlipressin-induced skin necrosis is anextremely rare ischemic event."Leiva-Salinas M, et al. Extensive cutaneous necrosis induced by terlipressin.Journal of the American Academy of Dermatology 70: AB151 abstr. P8608, No.51, 1 May 2014 - Spain 803102015
1
Reactions 19 Apr 2014 No. 14970114-9954/14/1497-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
